trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester

Base Information

Chemical Name:trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester
CAS No.:1207541-14-7
Molecular Formula:C₁₉H₁₆F₃N₃O₄S
Molecular Weight:439.415
Hs Code.:

Synonyms:trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester

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Chemical Property of trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester

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Technology Process of trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester

There total 3 articles about trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ol

: 1207541-14-7
trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 3222-56-8
2-methylnicotinic acid

: 1207541-14-7
trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -65 - 0 °C / Inert atmosphere

1.2: -65 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

With pyridine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 10282-31-2
4-morpholinobenzonitrile

: 1207541-14-7
trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -65 - 0 °C / Inert atmosphere

1.2: -65 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

With pyridine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;