7-(3-aminomethyl-4-difluoromethoxyimino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate

Base Information

Chemical Name:7-(3-aminomethyl-4-difluoromethoxyimino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate
CAS No.:1356948-30-5
Molecular Formula:CH₄O₃S*C₂₁H₁₆F₅N₅O₄
Molecular Weight:593.488
Hs Code.:

7-(3-aminomethyl-4-difluoromethoxyimino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate

Synonyms:7-(3-aminomethyl-4-difluoromethoxyimino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate

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Chemical Property of 7-(3-aminomethyl-4-difluoromethoxyimino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate

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Technology Process of 7-(3-aminomethyl-4-difluoromethoxyimino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate

There total 3 articles about 7-(3-aminomethyl-4-difluoromethoxyimino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-75-2,98527-29-8
methanesulfonic acid

: 1356948-16-7
C₂₈H₂₀F₅N₅O₄

: 1356948-30-5
7-(3-aminomethyl-4-difluoromethoxyimino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate

Guidance literature:: In chloroform; water; at 20 ℃; for 16h;
DOI:10.1016/j.ejmech.2011.10.048

Reference yield:

: 3-aminomethyl-4-(difluoromethoxyimino)pyrrolidine dimethanesulfonate

: 1356948-30-5
7-(3-aminomethyl-4-difluoromethoxyimino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / 2 h / 20 °C

2: dimethyl sulfoxide / 12 h / 20 °C

3: chloroform; water / 16 h / 20 °C

With triethylamine; In chloroform; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.ejmech.2011.10.048

Reference yield:

: C₁₃H₁₅F₂N₃O

: 1356948-30-5
7-(3-aminomethyl-4-difluoromethoxyimino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 12 h / 20 °C

2: chloroform; water / 16 h / 20 °C

In chloroform; water; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.10.048