1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester

Base Information

Chemical Name:1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester
CAS No.:331282-09-8
Molecular Formula:C₂₆H₂₆Cl₂N₄O₃
Molecular Weight:513.423
Hs Code.:

1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6<i>H</i>-imidazo[4,5-<i>d</i>][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester

Synonyms:1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester

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Chemical Property of 1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester

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Technology Process of 1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester

There total 10 articles about 1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91307-39-0
ethyl 1,2,3,4-tetrahydro-4-hydroxy-2-naphthoate

: 331282-09-8
1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / H₂ / 20percent Pd(OH)2/C / methanol / 48 h / 760.05 Torr

2: 86 percent / 1 N NaOH / dioxane / 36 h / 70 °C

3: 96 percent / Cs₂CO₃ / dimethylformamide / 18 h / -20 - 0 °C

4: 74 percent / SO₂Cl₂ / CH₂Cl₂ / 0.5 h / 0 °C

5: pyridine

6: (PPh₃)2PdCl₂; LiCl / dimethylformamide

7: HBr; benzoyl peroxide / hexane / 2 h / 20 °C

8: NaH; NaI / dimethylformamide

9: NaBH₄ / methanol; CH₂Cl₂

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; sodium tetrahydroborate; sulfuryl dichloride; hydrogen bromide; hydrogen; sodium hydride; caesium carbonate; sodium iodide; lithium chloride; dibenzoyl peroxide; 20percent Pd(OH)2/C; In 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000355t

Reference yield:

: 331282-31-6
1,3-dichloro-4-[2-(8-oxo-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester

: 331282-09-8
1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; dichloromethane;
DOI:10.1021/jm000355t

Reference yield:

: 66979-47-3
ethyl 2-oxo-5,6,7,8-tetrahydro-2H-1-benzopyran-3-carboxylate

: 331282-09-8
1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: toluene / Heating

2: 86 percent / 1 N NaOH / dioxane / 36 h / 70 °C

3: 96 percent / Cs₂CO₃ / dimethylformamide / 18 h / -20 - 0 °C

4: 74 percent / SO₂Cl₂ / CH₂Cl₂ / 0.5 h / 0 °C

5: pyridine

6: (PPh₃)2PdCl₂; LiCl / dimethylformamide

7: HBr; benzoyl peroxide / hexane / 2 h / 20 °C

8: NaH; NaI / dimethylformamide

9: NaBH₄ / methanol; CH₂Cl₂

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; sodium tetrahydroborate; sulfuryl dichloride; hydrogen bromide; sodium hydride; caesium carbonate; sodium iodide; lithium chloride; dibenzoyl peroxide; In 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm000355t