91307-39-0

Basic information

• Product Name: ethyl 4-hydroxy-2-naphthoate
• Synonyms: Ethyl 4-hydroxynaphthalene-2-carboxylate;ethyl 4-hydroxy-2-naphthoate
• CAS NO: 91307-39-0
• Molecular Formula: C₁₃H₁₂O₃
• Molecular Weight: 216.23
• Mol File: 91307-39-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 139-141 °C
• Boiling Point: 401.6°C at 760 mmHg
• Flash Point: 176.7°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 5.04E-07mmHg at 25°C
• Refractive Index: 1.625
• PKA: 8.63±0.40(Predicted)
• CAS DataBase Reference: ethyl 4-hydroxy-2-naphthoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-hydroxy-2-naphthoate(91307-39-0)
• EPA Substance Registry System: ethyl 4-hydroxy-2-naphthoate(91307-39-0)

Safety Data

• Hazardous Substances Data: 91307-39-0(Hazardous Substances Data)

Usage

General Description

Ethyl 4-hydroxy-2-naphthoate, also known as ethyl-4-hydroxy-2-naphthalene carboxylate, is a synthetic organic compound commonly used as a UV filter in sunscreen and other personal care products. It belongs to the family of naphthalene carboxylic acid esters and is derived from naphthalene, a polycyclic aromatic hydrocarbon. Ethyl 4-hydroxy-2-naphthoate absorbs and scatters UV radiation, providing protection against sunburn and skin damage. However, there are concerns about its potential for skin irritation, allergic reactions, and environmental toxicity, prompting some countries to regulate and restrict its use in cosmetics. Further research is needed to fully understand the safety and environmental impacts of ethyl 4-hydroxy-2-naphthoate.

InChI:InChI=1/C13H12O3/c1-2-16-13(15)10-7-9-5-3-4-6-11(9)12(14)8-10/h3-8,14H,2H2,1H3

Upstream product

• 136131-48-1 2-(ethoxycarbonyl)-1,4-dihydro-1,4-epoxynaphthalene 
• 64-17-5 ethanol 
• 1573-91-7 3-hydroxynaphthoic acid 
• 33295-46-4 ethyl 4-acetoxynaphthalene-2-carboxylate 
• 118-92-3 anthranilic acid 

Downstream Products

• 92190-54-0 4-methoxynaphthalene-2-carboxylic acid ethyl ester 
• 1257403-39-6 ethyl 2-[2,2-bis(4-methoxyphenyl)vinyl]-2-phenyl-2H-naphtho[1,2-b]pyran-5-carboxylate 
• 1257403-40-9 ethyl 2-(4-methoxyphenyl)-2-phenyl-2H-naphtho[1,2-b]pyran-5-carboxylate 
• 188863-64-1 ethyl 4-(benzyloxy)-2-naphthoate 
• 216310-14-4 Methanesulfonic acid 5-benzyloxy-3-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-ylmethyl ester 
• 216310-12-2 (5-Benzyloxy-3-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)-methanol 
• 216310-09-7 4-Benzyloxy-1-bromo-2-(1-methoxy-but-3-enyl)-naphthalene 
• 216310-10-0 5-Benzyloxy-3-methoxy-1-methylene-2,3-dihydro-1H-cyclopenta[a]naphthalene 
• 216310-08-6 1-(4-Benzyloxy-1-bromo-naphthalen-2-yl)-but-3-en-1-ol 
• 216310-06-4 (4-Benzyloxy-1-bromo-naphthalen-2-yl)-methanol 
• 216310-07-5 4-Benzyloxy-1-bromo-naphthalene-2-carbaldehyde 
• 331282-09-8 1,3-dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester 
• 331282-31-6 1,3-dichloro-4-[2-(8-oxo-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid benzyl ester 
• 331282-03-2 benzyl 1-(2-bromoethyl)-2,4-dichloro-5,6,7,8-tetrahydro-3-naphthylcarboxylate 

Relevant articles and documents

Photoreaction of halomethyl substituted benzocyclic ketones with amines: Radical cyclization and ring expansion reactions promoted through photoinduced electron transfer processes

Photoreaction of ethyl 2-bromomethyl-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate 1a or other related compounds 1b-d with Me3SiCH2NEt2 in aqueous MeCN afforded ethyl 5-oxo-6,7,8,9-tetrahydrobenzocycloheptene-7-carboxylate 2a or corresponding ring expansion products 2a-d respectively.

Photoinduced electron-transfer reaction of α-bromomethyl-substituted benzocyclic β-keto esters with amines: Selective reaction pathways depending on the nature of the amine radical cations

Photoinduced electron-transfer reaction of α-bromomethyl-substituted benzocyclic β-keto esters with tertiary amines was investigated. Debrominated β-keto esters and ring-expanded γ-keto esters were obtained as major products. On the basis of mechanistic experiments it was concluded that these products are formed via a reaction sequence of selective carbon-bromine bond cleavage and subsequent competitive hydrogen abstraction and Dowd-Beckwith ring-expansion of the resulting primary alkyl radicals. The characteristic product distribution observed for the type of amine used is rationalized on the basis of selective reaction pathways of generated radical intermediates that depend on the nature of the amine radical cations.

MORPHOLINE DERIVATIVE

The present invention provides a morpholine derivative of the formula [I]; wherein R1 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, a cycloalkyl group or an alkyl group; R2 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, an optionally substituted alkylcarbonyl group, an optionally substituted arylcarbonyl group, an optionally substituted heterocyclo-substituted carbonyl group or a cycloalkylcarbonyl group; T is a methylene group or a carbonyl group; R3, R4, R5 and R6 are the same or different and a hydrogen atom, an optionally substituted carbamoyl group or an optionally substituted alkyl group; or pharmaceutically acceptable salts thereof. These compounds are useful as a renin inhibitor.