(S)-ethyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

Base Information

Chemical Name:(S)-ethyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate
CAS No.:1396788-12-7
Molecular Formula:C₁₆H₂₁BrF₃NO₃S
Molecular Weight:444.313
Hs Code.:

Synonyms:(S)-ethyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

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Chemical Property of (S)-ethyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

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Technology Process of (S)-ethyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

There total 4 articles about (S)-ethyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1396788-11-6
(R,E)-N-(1-(5-bromo-2-fluorophenyl)-2,2-difluoroethylidene)-2-methylpropane-2-sulfinamide

: 105-36-2
ethyl bromoacetate

: 1396788-12-7
(S)-ethyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

Guidance literature:: ethyl bromoacetate; With copper(l) chloride; zinc; In tetrahydrofuran; at 50 ℃; for 0.5h; Inert atmosphere;

(R,E)-N-(1-(5-bromo-2-fluorophenyl)-2,2-difluoroethylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; at -20 ℃; Inert atmosphere;
DOI:10.1021/jm400225m

Reference yield:

: 1262858-97-8
1-(5-bromo-2-fluorophenyl)-2,2-difluoroethanone

: 1396788-12-7
(S)-ethyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 50 - 70 °C / Inert atmosphere

2.1: zinc; copper(l) chloride / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

2.2: -20 °C / Inert atmosphere

With titanium(IV) tetraethanolate; copper(l) chloride; zinc; In tetrahydrofuran; 2.2: |Reformatsky Reaction;
DOI:10.1021/jm400225m

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1396788-12-7
(S)-ethyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -70 - -10 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 50 - 70 °C / Inert atmosphere

3.1: zinc; copper(l) chloride / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

3.2: -20 °C / Inert atmosphere

With titanium(IV) tetraethanolate; copper(l) chloride; zinc; lithium diisopropyl amide; In tetrahydrofuran; 3.2: |Reformatsky Reaction;
DOI:10.1021/jm400225m