4-(1-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine

Base Information

Chemical Name:4-(1-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine
CAS No.:951743-87-6
Molecular Formula:C₂₃H₂₆N₄O₄
Molecular Weight:422.484
Hs Code.:

Synonyms:4-(1-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine

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Chemical Property of 4-(1-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine

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Technology Process of 4-(1-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine

There total 10 articles about 4-(1-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₉N₅O₆

: 951743-87-6
4-(1-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine

Guidance literature:: With potassium carbonate; In methanol; at 60 ℃; for 5h;

Reference yield:

: 498-94-2
isonipecotic acid

: 951743-87-6
4-(1-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydrogencarbonate / water / 20 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 - 2 h / 0 - 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.67 h / -78 °C

3.2: 1 h / -78 °C

4.1: hydrogenchloride / methanol / 3 h / 20 °C

4.2: 0.5 h

4.3: 15 h / 80 °C

5.1: hydrogen / ASCA-2 / methanol / 5 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

7.1: triethylamine / tetrahydrofuran / 3 h / 55 °C

8.1: potassium carbonate / methanol / 5 h / 60 °C

With hydrogenchloride; n-butyllithium; oxalyl dichloride; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; hexane; dichloromethane; water;

Reference yield:

: 951745-35-0
1-benzyloxycarbonyl-4-(1-(4-(benzyloxy)phenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

: 951743-87-6
4-(1-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / ASCA-2 / methanol / 5 h / 20 °C

2: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

3: triethylamine / tetrahydrofuran / 3 h / 55 °C

4: potassium carbonate / methanol / 5 h / 60 °C

With hydrogen; potassium carbonate; triethylamine; ASCA-2; In tetrahydrofuran; methanol;