1-benzyloxycarbonyl-4-(1-(4-(benzyloxy)phenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

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Chemical Name:1-benzyloxycarbonyl-4-(1-(4-(benzyloxy)phenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine
CAS No.:951745-35-0
Molecular Formula:C₃₆H₃₅N₃O₄
Molecular Weight:573.692
Hs Code.:

Synonyms:1-benzyloxycarbonyl-4-(1-(4-(benzyloxy)phenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

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Chemical Property of 1-benzyloxycarbonyl-4-(1-(4-(benzyloxy)phenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

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Technology Process of 1-benzyloxycarbonyl-4-(1-(4-(benzyloxy)phenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

There total 8 articles about 1-benzyloxycarbonyl-4-(1-(4-(benzyloxy)phenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 951744-24-4
1-Benzyloxycarbonyl-4-(3-(4-methoxyphenyl)-1,3-dioxopropyl)piperidine

: 951745-34-9
N-amino-N-tert-butoxycarbonyl(4-benzyloxy)aniline

: 951745-35-0
1-benzyloxycarbonyl-4-(1-(4-(benzyloxy)phenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

Guidance literature:: N-amino-N-tert-butoxycarbonyl(4-benzyloxy)aniline; With hydrogenchloride; In methanol; at 20 ℃; for 3h;

With triethylamine; In ethanol; for 0.5h;

1-Benzyloxycarbonyl-4-(3-(4-methoxyphenyl)-1,3-dioxopropyl)piperidine; In ethanol; at 80 ℃; for 15h;

Reference yield:

: 498-94-2
isonipecotic acid

: 951745-35-0
1-benzyloxycarbonyl-4-(1-(4-(benzyloxy)phenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water / 20 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 - 2 h / 0 - 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.67 h / -78 °C

3.2: 1 h / -78 °C

4.1: hydrogenchloride / methanol / 3 h / 20 °C

4.2: 0.5 h

4.3: 15 h / 80 °C

With hydrogenchloride; n-butyllithium; oxalyl dichloride; sodium hydrogencarbonate; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; hexane; dichloromethane; water;

Reference yield:

: 540-38-5
p-Iodophenol

: 951745-35-0
1-benzyloxycarbonyl-4-(1-(4-(benzyloxy)phenyl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: 1,10-Phenanthroline; caesium carbonate / copper(l) iodide / N,N-dimethyl-formamide / 15 h / 80 °C

3.1: hydrogenchloride / methanol / 3 h / 20 °C

3.2: 0.5 h

3.3: 15 h / 80 °C

With hydrogenchloride; 1,10-Phenanthroline; potassium carbonate; caesium carbonate; copper(l) iodide; In methanol; N,N-dimethyl-formamide;