(R)-benzyl 2-[(S)-1-(benzyloxy)propyl]-2,5-dihydro-1H-pyrrole-1-carboxylate

Base Information

Chemical Name:(R)-benzyl 2-[(S)-1-(benzyloxy)propyl]-2,5-dihydro-1H-pyrrole-1-carboxylate
CAS No.:1403599-38-1
Molecular Formula:C₂₂H₂₅NO₃
Molecular Weight:351.445
Hs Code.:

Synonyms:(R)-benzyl 2-[(S)-1-(benzyloxy)propyl]-2,5-dihydro-1H-pyrrole-1-carboxylate

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Chemical Property of (R)-benzyl 2-[(S)-1-(benzyloxy)propyl]-2,5-dihydro-1H-pyrrole-1-carboxylate

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Technology Process of (R)-benzyl 2-[(S)-1-(benzyloxy)propyl]-2,5-dihydro-1H-pyrrole-1-carboxylate

There total 4 articles about (R)-benzyl 2-[(S)-1-(benzyloxy)propyl]-2,5-dihydro-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1403599-37-0
benzyl allyl[(3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-yl]carbamate

: 1403599-38-1
(R)-benzyl 2-[(S)-1-(benzyloxy)propyl]-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 12h; Inert atmosphere; Reflux;
DOI:10.1002/ejoc.201200489

Reference yield:

: C₂₇H₂₈ClNO₅S

: 1403599-38-1
(R)-benzyl 2-[(S)-1-(benzyloxy)propyl]-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium sulfite / water; toluene / 6 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C / Inert atmosphere

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 12 h / Inert atmosphere; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydride; sodium sulfite; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1002/ejoc.201200489

Reference yield:

: 1403599-33-6
benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate

: 1403599-38-1
(R)-benzyl 2-[(S)-1-(benzyloxy)propyl]-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C / Inert atmosphere

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 12 h / Inert atmosphere; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.201200489