benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate

Base Information

• Chemical Name: benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate
• CAS No.: 1403599-33-6
• Molecular Formula: C₂₇H₂₉NO₃
• Molecular Weight: 415.532
• Mol file: 1403599-33-6.mol

Synonyms:benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate

Chemical Property of benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate

There total 2 articles about benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H28ClNO5S → benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate (1403599-33-6)

Guidance literature:

With sodium sulfite; In water; toluene; at 20 ℃; for 6h; optical yield given as %de; Inert atmosphere;

DOI:10.1002/ejoc.201200489

Reference yield:

(3R,4S)-1-phenylhex-1-ene-3,4-diyl-bis(oxy)bis(methylene)dibenzene → benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate (1403599-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / toluene / 16 h / 0 °C / Inert atmosphere

2: sodium sulfite / water; toluene / 6 h / 20 °C / Inert atmosphere

With sodium carbonate; sodium sulfite; In water; toluene;

DOI:10.1002/ejoc.201200489

Reference yield: 95.0%

benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate (1403599-33-6) + allyl bromide (106-95-6) → benzyl allyl[(3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-yl]carbamate (1403599-37-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ejoc.201200489

Downstream raw materials:

(3R,4S,Z)-4-(benzyloxy)-1-phenylhex-1-en-3-amine

(R)-6-[(S)-1-(benzyloxy)propyl]-1,2,3,6-tetrahydropyridine

(R)-benzyl 2-[(S)-1-(benzyloxy)propyl]-2,5-dihydro-1H-pyrrole-1-carboxylate

(S)-1-[(R)-piperidin-2-yl]propan-1-ol [(-)-α-conhydrine]