1,7,7-Trimethyl-2-exo-piperidinobicyclo(2.2.1)heptan-3-endo-ol p-amino benzoate (ester)

Base Information

• Chemical Name: 1,7,7-Trimethyl-2-exo-piperidinobicyclo(2.2.1)heptan-3-endo-ol p-amino benzoate (ester)
• CAS No.: 77156-02-6
• Molecular Formula: C₂₂H₃₂N₂O₂
• Molecular Weight: 356.508
• Mol file: 77156-02-6.mol

Synonyms:1,7,7-Trimethyl-2-exo-piperidinobicyclo(2.2.1)heptan-3-endo-ol p-amino benzoate (ester)

Chemical Property of 1,7,7-Trimethyl-2-exo-piperidinobicyclo(2.2.1)heptan-3-endo-ol p-amino benzoate (ester)

Chemical Property:

• Vapor Pressure: 1.28E-09mmHg at 25°C
• Boiling Point: 486.5°C at 760 mmHg
• Flash Point: 248.1°C
• PSA: 55.56000
• Density: 1.14g/cm³
• LogP: 4.62390

Purity/Quality:

1,7,7-TRIMETHYL-2-EXO-PIPERIDINOBICYCLO(2.2.1)HEPTAN-3-ENDO-OL P-AMINO BENZOATE (ESTER) 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,7,7-Trimethyl-2-exo-piperidinobicyclo(2.2.1)heptan-3-endo-ol p-amino benzoate (ester)

There total 3 articles about 1,7,7-Trimethyl-2-exo-piperidinobicyclo(2.2.1)heptan-3-endo-ol p-amino benzoate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-Nitro-benzoic acid (1S,2S,3S,4R)-4,7,7-trimethyl-3-piperidin-1-yl-bicyclo[2.2.1]hept-2-yl ester → 4-Amino-benzoic acid (1S,2S,3S,4R)-4,7,7-trimethyl-3-piperidin-1-yl-bicyclo[2.2.1]hept-2-yl ester (77156-02-6)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate; Ambient temperature;

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → 4-Amino-benzoic acid (1S,2S,3S,4R)-4,7,7-trimethyl-3-piperidin-1-yl-bicyclo[2.2.1]hept-2-yl ester (77156-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-buthyllithium / 1.) hexane, tetrahydrofuran, 15 min, 15 deg C; 2.) hexane, tetrahydrofuran, reflux, 12 h

2: 98 percent / hydrogen / PtO₂ / ethyl acetate / Ambient temperature

With n-butyllithium; hydrogen; platinum(IV) oxide; In ethyl acetate;

Reference yield:

1,7,7-trimethyl-2-exo-piperidinobicyclo<2.2.1>heptan-3-endo-ol → 4-Amino-benzoic acid (1S,2S,3S,4R)-4,7,7-trimethyl-3-piperidin-1-yl-bicyclo[2.2.1]hept-2-yl ester (77156-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-buthyllithium / 1.) hexane, tetrahydrofuran, 15 min, 15 deg C; 2.) hexane, tetrahydrofuran, reflux, 12 h

2: 98 percent / hydrogen / PtO₂ / ethyl acetate / Ambient temperature

With n-butyllithium; hydrogen; platinum(IV) oxide; In ethyl acetate;

upstream raw materials:

4-nitro-benzoyl chloride

Refernces