4-chloro-3'-fluoro-3-methyl-6-{1-[(9H-purin-6-yl)amino]ethyl}-[1,1'-biphenyl]-2-carbonitrile

Base Information

Chemical Name:4-chloro-3'-fluoro-3-methyl-6-{1-[(9H-purin-6-yl)amino]ethyl}-[1,1'-biphenyl]-2-carbonitrile
CAS No.:1382992-83-7
Molecular Formula:C₂₁H₁₆ClFN₆
Molecular Weight:406.85
Hs Code.:

Synonyms:4-chloro-3'-fluoro-3-methyl-6-{1-[(9H-purin-6-yl)amino]ethyl}-[1,1'-biphenyl]-2-carbonitrile

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Chemical Property of 4-chloro-3'-fluoro-3-methyl-6-{1-[(9H-purin-6-yl)amino]ethyl}-[1,1'-biphenyl]-2-carbonitrile

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Technology Process of 4-chloro-3'-fluoro-3-methyl-6-{1-[(9H-purin-6-yl)amino]ethyl}-[1,1'-biphenyl]-2-carbonitrile

There total 7 articles about 4-chloro-3'-fluoro-3-methyl-6-{1-[(9H-purin-6-yl)amino]ethyl}-[1,1'-biphenyl]-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382995-00-7
6-(1-aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-carbonitrile

: 767-69-1
6-bromopurine

: 1382992-83-7
4-chloro-3'-fluoro-3-methyl-6-{1-[(9H-purin-6-yl)amino]ethyl}-[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 90 ℃; Inert atmosphere; Reflux;
DOI:10.1021/acsmedchemlett.9b00334

Reference yield:

: 1-(3-bromo-5-chloro-2-hydroxy-4-methylphenyl)ethanone

: 1382992-83-7
4-chloro-3'-fluoro-3-methyl-6-{1-[(9H-purin-6-yl)amino]ethyl}-[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-methyl-pyrrolidin-2-one / 1 h / 200 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.5 h / -78 - 0 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; toluene / 2 h / 80 °C / Inert atmosphere

4.1: ammonium acetate / acetonitrile; methanol / 0.5 h / 60 °C / Inert atmosphere; Sealed tube

4.2: 4 h / 60 °C / Inert atmosphere; Sealed tube

5.1: N-ethyl-N,N-diisopropylamine / ethanol / 90 °C / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00334

Reference yield:

: 1312686-22-8
3-acetyl-5-chloro-2-hydroxy-6-methylbenzonitrile

: 1382992-83-7
4-chloro-3'-fluoro-3-methyl-6-{1-[(9H-purin-6-yl)amino]ethyl}-[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.5 h / -78 - 0 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; toluene / 2 h / 80 °C / Inert atmosphere

3.1: ammonium acetate / acetonitrile; methanol / 0.5 h / 60 °C / Inert atmosphere; Sealed tube

3.2: 4 h / 60 °C / Inert atmosphere; Sealed tube

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 90 °C / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00334