5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE

Base Information

• Chemical Name: 5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE
• CAS No.: 28480-70-8
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Hs Code.: 2914700090
• Mol file: 28480-70-8.mol

Synonyms:Acetophenone,5'-chloro-2'-hydroxy-4'-methyl- (6CI,8CI);2-Acetyl-4-chloro-5-methylphenol;5-Chloro-2-hydroxy-4-methylacetophenone;5-Chloro-4-methyl-2-hydroxyacetophenone;5'-Chloro-2'-hydroxy-4'-methylacetophenone;

Chemical Property of 5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE

Chemical Property:

• Melting Point: 70-73 °C(lit.)
• Boiling Point: 295 °C at 760 mmHg
• PKA: 9.84±0.23(Predicted)
• Flash Point: 132.2 °C
• PSA: 37.30000
• Density: 1.25 g/cm³
• LogP: 2.55660

Purity/Quality:

98%,99%, ^*data from raw suppliers

5''-Chloro-2''-hydroxy-4''-methylacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5′-Chloro-2′-hydroxy-4′-methylacetophenone (5-chloro-2-hydroxy-4-methylacetophenone) may be used in the preparation of the following:chalcones, required for the synthesis of novel pyrazoline derivatives5′-chloro-2′-hydroxy-4′-methyl-3-(2′′-thienyl)acrylophenone6-chloro-3-hydroxy-7-methyl-2-(2-thienyl)-4H-chromen-4-one, a complexing agent used for the spectrophotometric determination of vanadium(V)

Technology Process of 5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE

There total 7 articles about 5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-chloro-2-hydroxy-4-methyl-acetophenone oxime (38589-71-8) → 5'-chloro-2'-hydroxy-4'-methyl acetophenone (28480-70-8)

Guidance literature:

With sodium perborate; In acetic acid; for 5h; Heating;

DOI:10.1080/00397910008087181

Reference yield: 20.0%

4-chloro-3-methylphenyl acetate (54963-43-8) → 5'-chloro-2'-hydroxy-4'-methyl acetophenone (28480-70-8)

Guidance literature:

With aluminium trichloride; at 140 ℃; for 2h;

DOI:10.1211/146080899128734910

Reference yield:

4-Chloro-3-methylphenol (59-50-7) + acetyl chloride (75-36-5) → 5'-chloro-2'-hydroxy-4'-methyl acetophenone (28480-70-8)

Guidance literature:

4-Chloro-3-methylphenol; acetyl chloride; In toluene; at 40 ℃;

With aluminium trichloride; In toluene; at 80 ℃; Further stages.;

DOI:10.1021/jm061428x

upstream raw materials:

4-chloro-3-methylphenyl acetate

4-Chloro-3-methylphenol

acetic acid

4-chloro-2-isopropyl-5-methyl-anisole

Downstream raw materials:

6-Ethyl-3-methyl-p-Chlorophenol

(E)-1-(5-Chloro-2-hydroxy-4-methyl-phenyl)-3-naphthalen-1-yl-propenone

(E)-1-(5-Chloro-2-hydroxy-4-methyl-phenyl)-3-(2-hydroxy-phenyl)-propenone

3-(1-phenyl-3-thiophen-2-yl-1H-pyrazol-4-yl)-acrylic acid 2-acetyl-4-chloro-5-methyl-phenyl ester

Refernces

• 1、 Dofe, Vidya S.,Sarkate, Aniket P.,Shaikh, Zarina M.,Gill, Charansingh H.. "Ultrasound-assisted synthesis and antimicrobial activity of tetrazole-based pyrazole and pyrimidine derivatives". . p. 59 - 65. Retrieved 2018/01/18.
• 2、 Dalal, Aarti,Khanna, Radhika,Berar, Urmila,Kamboj, Ramesh C.. "Photochemistry of aroyloxiranes: Substituent effect on oxepinones and hydroxyalkenones formation". . p. 238 - 245. Retrieved 2016/07/22.