(1S,2R)-3-(tert-butyldimethylsilyloxy)-N₂,N₂-dimethyl-1-(4-nitrophenyl)propane-1,2-diamine

Base Information

• Chemical Name: (1S,2R)-3-(tert-butyldimethylsilyloxy)-N₂,N₂-dimethyl-1-(4-nitrophenyl)propane-1,2-diamine
• CAS No.: 1127228-51-6
• Molecular Formula: C₁₇H₃₁N₃O₃Si
• Molecular Weight: 353.537

Synonyms:(1S,2R)-3-(tert-butyldimethylsilyloxy)-N₂,N₂-dimethyl-1-(4-nitrophenyl)propane-1,2-diamine

Chemical Property of (1S,2R)-3-(tert-butyldimethylsilyloxy)-N₂,N₂-dimethyl-1-(4-nitrophenyl)propane-1,2-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-3-(tert-butyldimethylsilyloxy)-N₂,N₂-dimethyl-1-(4-nitrophenyl)propane-1,2-diamine

There total 1 articles about (1S,2R)-3-(tert-butyldimethylsilyloxy)-N₂,N₂-dimethyl-1-(4-nitrophenyl)propane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(1R,2S)-3-(tert-butyldimethylsilanyloxy)-2-dimethylamino-1-(4-nitrophenyl)propan-1-ol (1127228-49-2) → (1S,2R)-3-(tert-butyldimethylsilyloxy)-N2,N2-dimethyl-1-(4-nitrophenyl)propane-1,2-diamine (1127228-51-6)

Guidance literature:

(1R,2S)-3-(tert-butyldimethylsilanyloxy)-2-dimethylamino-1-(4-nitrophenyl)propan-1-ol; With di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine; In tetrahydrofuran; at 0 - 50 ℃; Inert atmosphere;

With triphenylphosphine; In tetrahydrofuran; at 50 ℃; for 2h; Inert atmosphere;

With water; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/adsc.200800761

Reference yield: 95.0%

(1S,2R)-3-(tert-butyldimethylsilyloxy)-N2,N2-dimethyl-1-(4-nitrophenyl)propane-1,2-diamine (1127228-51-6) + 3,5-bistrifluoromethylphenylisothiocyanate (23165-29-9) → 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-3-(tert-butyldimethylsilyloxy)-2-(dimethylamino)-1-(4-nitrophenyl)propyl)thiourea (1127228-52-7)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.200800761

upstream raw materials:

(1R,2S)-3-(tert-butyldimethylsilanyloxy)-2-dimethylamino-1-(4-nitrophenyl)propan-1-ol

Downstream raw materials:

1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-3-(tert-butyldimethylsilyloxy)-2-(dimethylamino)-1-(4-nitrophenyl)propyl)thiourea

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1127228-51-6 (1S,2R)-3-(tert-butyldimethylsilyloxy)-N₂,N₂-dimethyl-1-(4-nitrophenyl)propane-1,2-diamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send