4-(4-chlorophenoxy)-2-fluoro-N-(methylsulfonyl)-5-(2-propoxypyridin-3-yl)benzamide

Base Information

Chemical Name:4-(4-chlorophenoxy)-2-fluoro-N-(methylsulfonyl)-5-(2-propoxypyridin-3-yl)benzamide
CAS No.:1445862-62-3
Molecular Formula:C₂₂H₂₀ClFN₂O₅S
Molecular Weight:478.929
Hs Code.:

Synonyms:4-(4-chlorophenoxy)-2-fluoro-N-(methylsulfonyl)-5-(2-propoxypyridin-3-yl)benzamide

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Chemical Property of 4-(4-chlorophenoxy)-2-fluoro-N-(methylsulfonyl)-5-(2-propoxypyridin-3-yl)benzamide

Chemical Property:

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Technology Process of 4-(4-chlorophenoxy)-2-fluoro-N-(methylsulfonyl)-5-(2-propoxypyridin-3-yl)benzamide

There total 5 articles about 4-(4-chlorophenoxy)-2-fluoro-N-(methylsulfonyl)-5-(2-propoxypyridin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 1445862-89-4
4-(4-chlorophenoxy)-2-fluoro-5-iodo-N-(methylsulfonyl)benzamide

: 1073371-87-5
2-propoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1445862-62-3
4-(4-chlorophenoxy)-2-fluoro-N-(methylsulfonyl)-5-(2-propoxypyridin-3-yl)benzamide

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium hydrogencarbonate; In tetrahydrofuran; at 70 ℃; Inert atmosphere;

Reference yield:

: 161531-51-7
2,4-difluoro-5-iodobenzoic acid

: 1445862-62-3
4-(4-chlorophenoxy)-2-fluoro-N-(methylsulfonyl)-5-(2-propoxypyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / tert-butyl alcohol / 40 °C

2: potassium carbonate / dimethyl sulfoxide / 20 °C

3: water; hydrogenchloride / 1,4-dioxane / 48 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5: sodium hydrogencarbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 70 °C / Inert atmosphere

With hydrogenchloride; dmap; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 1445862-86-1
tert-butyl 2,4-diflouro-5-iodobenzoate

: 1445862-62-3
4-(4-chlorophenoxy)-2-fluoro-N-(methylsulfonyl)-5-(2-propoxypyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 20 °C

2: water; hydrogenchloride / 1,4-dioxane / 48 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

4: sodium hydrogencarbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 70 °C / Inert atmosphere

With hydrogenchloride; dmap; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;