(1S,2R,5S)-2,5-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1-(diethylamino)-1-oxo-2,5-dihydro-1H-phosphole

Base Information

Chemical Name:(1S,2R,5S)-2,5-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1-(diethylamino)-1-oxo-2,5-dihydro-1H-phosphole
CAS No.:1428255-73-5
Molecular Formula:C₃₈H₆₀NO₃P
Molecular Weight:609.873
Hs Code.:

Synonyms:(1S,2R,5S)-2,5-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1-(diethylamino)-1-oxo-2,5-dihydro-1H-phosphole

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Chemical Property of (1S,2R,5S)-2,5-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1-(diethylamino)-1-oxo-2,5-dihydro-1H-phosphole

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Technology Process of (1S,2R,5S)-2,5-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1-(diethylamino)-1-oxo-2,5-dihydro-1H-phosphole

There total 1 articles about (1S,2R,5S)-2,5-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1-(diethylamino)-1-oxo-2,5-dihydro-1H-phosphole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1069-08-5
diethylphosphoramidous dichloride

: 1261146-15-9
(1E,3E)-1,4-bis(3,5-di-tert-butyl-4-methoxyphenyl)buta-1,3-diene

: 1428255-73-5
(1S,2R,5S)-2,5-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1-(diethylamino)-1-oxo-2,5-dihydro-1H-phosphole

Guidance literature:: diethylphosphoramidous dichloride; (1E,3E)-1,4-bis(3,5-di-tert-butyl-4-methoxyphenyl)buta-1,3-diene; With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

With nitrilotriacetic acid; sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; for 4h; Inert atmosphere;
DOI:10.1055/s-0032-1316835

Reference yield:

: 1428255-73-5
(1S,2R,5S)-2,5-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1-(diethylamino)-1-oxo-2,5-dihydro-1H-phosphole

: 1428255-86-0
(1R,5R)-1-diethylamino-1-oxo-2,5-bis(3,5-di-tert-butyl-4-methoxyphenyl)-4,5-dihydro-1H-phosphole

: (1S,5S)-1-diethylamino-1-oxo-2,5-bis(3,5-di-tert-butyl-4-methoxyphenyl)-4,5-dihydro-1H-phosphole

Guidance literature:: With Cinchonin; In acetonitrile; at 80 ℃; for 100h; Overall yield = 94 %; Overall yield = 0.188 g; enantioselective reaction;
DOI:10.1055/s-0032-1316835