Technology Process of (1E,3E)-1,4-bis(3,5-di-tert-butyl-4-methoxyphenyl)buta-1,3-diene
There total 9 articles about (1E,3E)-1,4-bis(3,5-di-tert-butyl-4-methoxyphenyl)buta-1,3-diene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl (3,5-di-tert-butyl-4-methoxybenzyl)phosphonate;
With
potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.333333h;
Schlenk technique;
Inert atmosphere;
(E)-3-(3,5-di-tert-butyl-4-methoxyphenyl)acrylaldehyde;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/ejoc.202000336
- Guidance literature:
-
thiophene; 3,5-di(tert-butyl)-4-methoxyphenylmagnesium bromide;
With
1,3-bis(mesityl)imidazolium chloride; nickel(II) acetylacetonate;
In
tetrahydrofuran; toluene;
at 80 ℃;
for 36h;
Inert atmosphere;
With
iodine;
In
hexane;
at 20 ℃;
Inert atmosphere;
Irradiation;
DOI:10.1002/adsc.201000350
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 2,4,6-trimethylaniline / dichloromethane / 3.5 h / 25 °C
2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere; Schlenk technique
3.1: diisobutylaluminium hydride / dichloromethane; hexane / 2.5 h / 0 °C / Inert atmosphere; Schlenk technique
4.1: manganese(IV) oxide / dichloromethane / 20 °C / Inert atmosphere; Schlenk technique
5.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Schlenk technique; Inert atmosphere
5.2: 2 h / 20 °C / Inert atmosphere; Schlenk technique
With
manganese(IV) oxide; potassium tert-butylate; palladium diacetate; diisobutylaluminium hydride; triethylamine; 2,4,6-trimethylaniline; tris-(o-tolyl)phosphine;
In
hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.202000336
