1-benzyl-4-<2'--3'-hydroxypropyl>imidazole

Base Information

• Chemical Name: 1-benzyl-4-<2'--3'-hydroxypropyl>imidazole
• CAS No.: 119998-69-5
• Molecular Formula: C₂₃H₂₇N₃O₃
• Molecular Weight: 393.486
• Mol file: 119998-69-5.mol

Synonyms:1-benzyl-4-<2'--3'-hydroxypropyl>imidazole

Chemical Property of 1-benzyl-4-<2'--3'-hydroxypropyl>imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-<2'--3'-hydroxypropyl>imidazole

There total 3 articles about 1-benzyl-4-<2'--3'-hydroxypropyl>imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

1-benzyl-4-<2'-(ethylamino)-3'-hydroxypropyl>imidazole (119998-68-4) + benzyl chloroformate (501-53-1,94274-21-2) → 1-benzyl-4-<2'--3'-hydroxypropyl>imidazole (119998-69-5)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; for 0.75h; Ambient temperature;

DOI:10.1021/jm00126a030

Reference yield:

1-benzyl-L-histidine benzyl ester (42569-10-8) → 1-benzyl-4-<2'--3'-hydroxypropyl>imidazole (119998-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / acetic acid / 0.75 h / Heating

2: 43 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

3: 32 percent / aq. LiOH / dioxane / 0.75 h / Ambient temperature

With lithium hydroxide; lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm00126a030

Reference yield:

N-acetyl-1-benzyl-L-histidine benzyl ester (119998-67-3) → 1-benzyl-4-<2'--3'-hydroxypropyl>imidazole (119998-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

2: 32 percent / aq. LiOH / dioxane / 0.75 h / Ambient temperature

With lithium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm00126a030

upstream raw materials:

1-benzyl-4-<2'-(ethylamino)-3'-hydroxypropyl>imidazole

benzyl chloroformate

1-benzyl-L-histidine benzyl ester

N-acetyl-1-benzyl-L-histidine benzyl ester

Downstream raw materials:

3-Benzyl-5-((S)-3-ethyl-2-oxo-oxazolidin-4-ylmethyl)-1-methyl-3H-imidazol-1-ium; iodide

(S)-3-ethyl-4-<(1'-benzyl-4'-imidazolyl)methyl>-2-oxazolidinone