2,2,5-trimethyl-7-(prop-2-yn-1-yloxy)-2H-chromene

Base Information

• Chemical Name: 2,2,5-trimethyl-7-(prop-2-yn-1-yloxy)-2H-chromene
• CAS No.: 94244-09-4
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.291
• Mol file: 94244-09-4.mol

Synonyms:

Chemical Property of 2,2,5-trimethyl-7-(prop-2-yn-1-yloxy)-2H-chromene

Chemical Property:

• Vapor Pressure: 0.000121mmHg at 25°C
• Boiling Point: 345.6°C at 760 mmHg
• Flash Point: 136.2°C
• Density: 1.056g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,5-trimethyl-7-(prop-2-yn-1-yloxy)-2H-chromene

There total 5 articles about 2,2,5-trimethyl-7-(prop-2-yn-1-yloxy)-2H-chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,5-Trimethyl-7-prop-2-ynyloxy-chroman-4-ol → 2,2,5-Trimethyl-7-prop-2-ynyloxy-2H-chromene (94244-09-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 25 ℃; for 3h; Yield given;

Reference yield:

7-Hydroxy-2,2,5-trimethyl-4-chromanone (20052-60-2) → 2,2,5-Trimethyl-7-prop-2-ynyloxy-2H-chromene (94244-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / K₂CO₃, KI / dimethylformamide / 10 h / 80 °C

2: NaBH₄ / methanol / 4 h / 25 °C

3: 4M HCl / tetrahydrofuran / 3 h / 25 °C

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; potassium iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

3-Methylbutenoic acid (541-47-9) → 2,2,5-Trimethyl-7-prop-2-ynyloxy-2H-chromene (94244-09-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / POCl₃, ZnCl₂ / 2 h / 50 °C

2: 95 percent / K₂CO₃, KI / dimethylformamide / 10 h / 80 °C

3: NaBH₄ / methanol / 4 h / 25 °C

4: 4M HCl / tetrahydrofuran / 3 h / 25 °C

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; potassium iodide; zinc(II) chloride; trichlorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

7-Hydroxy-2,2,5-trimethyl-4-chromanone

3-Methylbutenoic acid

2,2,5-Trimethyl-7-prop-2-ynyloxy-chroman-4-one

5-Methylresorcinol monohydrate

Refernces