4-(4-Chlorophenyl)-1-(4-methoxybenzoyl)-2-pyrrolidinone

Base Information

Chemical Name:4-(4-Chlorophenyl)-1-(4-methoxybenzoyl)-2-pyrrolidinone
CAS No.:137427-79-3
Molecular Formula:C₁₈H₁₆ClNO₃
Molecular Weight:329.783
Hs Code.:
DSSTox Substance ID:DTXSID30929790
ChEMBL ID:CHEMBL1413537
Mol file:137427-79-3.mol

Synonyms:137427-79-3;4-(4-Chlorophenyl)-1-(4-methoxybenzoyl)-2-pyrrolidinone;4-(4-chlorophenyl)-1-(4-methoxybenzoyl)pyrrolidin-2-one;2-Pyrrolidinone, 4-(4-chlorophenyl)-1-(4-methoxybenzoyl)-;CBMicro_019119;Oprea1_217508;Oprea1_579269;MLS001076056;SCHEMBL9263597;CHEMBL1413537;DTXSID30929790;UGMOFEZUZCRWSE-UHFFFAOYSA-N;HMS2782J19;CCG-7130;AKOS000549135;SMR000473139;BIM-0019092.P001;LS-138671

Suppliers and Price of 4-(4-Chlorophenyl)-1-(4-methoxybenzoyl)-2-pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-(4-Chlorophenyl)-1-(4-methoxybenzoyl)-2-pyrrolidinone

Chemical Property:

Vapor Pressure:9.09E-11mmHg at 25°C
Boiling Point:516.3°Cat760mmHg
Flash Point:266.1°C
PSA：46.61000
Density:1.301g/cm³
LogP:3.44280
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:329.0818711
Heavy Atom Count:23
Complexity:440

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(=O)N2CC(CC2=O)C3=CC=C(C=C3)Cl

Technology Process of 4-(4-Chlorophenyl)-1-(4-methoxybenzoyl)-2-pyrrolidinone

There total 2 articles about 4-(4-Chlorophenyl)-1-(4-methoxybenzoyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 22518-27-0
4-(4-chlorophenyl)pyrrolidin-2-one

: 100-07-2
4-methoxy-benzoyl chloride

: 137427-79-3
4-(4-chlorophenyl)-1-(4-methoxybenzoyl)-pyrrolid-2-one

Guidance literature:: With triethylamine; In tetrahydrofuran; at 50 ℃; for 3h;

Reference yield:

: 1134-47-0
4-amino-3-(4-chlorophenyl)butanoic acid

: 137427-79-3
4-(4-chlorophenyl)-1-(4-methoxybenzoyl)-pyrrolid-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / SiO₂ / toluene / 6 h / Heating

2: 18 percent / Et₃N / tetrahydrofuran / 3 h / 50 °C

With silica gel; triethylamine; In tetrahydrofuran; toluene;