(R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

Base Information

Chemical Name:(R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate
CAS No.:1318802-50-4
Molecular Formula:C₂₂H₂₀Cl₃NO₅
Molecular Weight:484.763
Hs Code.:

Synonyms:(R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

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Chemical Property of (R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

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Technology Process of (R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

There total 4 articles about (R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1060771-60-9
4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

: 1318802-50-4
(R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

Guidance literature:: With C₈₂H₈₂ClIrN₅O₂⁽¹⁺⁾*F₆P^(1-); caesium carbonate; In ethyl acetate; at -30 ℃; for 72h; enantioselective reaction;
DOI:10.1021/acscatal.7b01296

Reference yield:

: 1060771-60-9
4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

: 1,1,1-trichloro-2-methylpropan-2-yl (S)-4-benzyl-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

: 1318802-50-4
(R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

Guidance literature:: With (S)-5-benzyl-6,6-dimethyl-2-phenyl-5,6-dihydrooxazolo[2,3-c][1,2,4]triazol-2-ium tetrafluoroborate; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 20 ℃; for 1h; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tetasy.2011.04.001

Reference yield:

: 880264-76-6
2-(4-methoxyphenyl)-4-methyloxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

: 217446-10-1
O-benzyloxycarbonyl-2-(4-methoxyphenyl)-4-benzyldihydroazolone

: (R)-1,1,1-trichloro-2-methylpropan-2-yl-2-(4-methoxyphenyl)-4-methyl-5-oxo-4,5-dihydrooxazole-4-carboxylate

: 1318802-50-4
(R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

: 627877-70-7
(R)-4-methyl-5-oxo-2-(4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

: 4-benzyl-5-oxo-2-(4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxylic acid benzyl ester

Guidance literature:: With 4-pyrrolidinyl-3-(2-(2,6-diisopropylbenzamide)pyrrolidinyl)pyridine-1-oxide; In toluene; at 0 ℃;
DOI:10.1002/anie.201812864