4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

Base Information

• Chemical Name: 4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate
• CAS No.: 1060771-60-9
• Molecular Formula: C₂₂H₂₀Cl₃NO₅
• Molecular Weight: 484.763

Synonyms:4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

Chemical Property of 4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

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Technology Process of 4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

There total 1 articles about 4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,2,2-trichloro-1,1-dimethylethoxychloroformate (66270-36-8) + 4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole (217446-35-0) → 4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate (1060771-60-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 25 ℃;

DOI:10.1039/b805850d

Reference yield: 99.0%

4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate (1060771-60-9) → (R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate (1318802-50-4)

Guidance literature:

With C₈₂H₈₂ClIrN₅O₂⁽¹⁺⁾*F₆P^(1-); caesium carbonate; In ethyl acetate; at -30 ℃; for 72h; enantioselective reaction;

DOI:10.1021/acscatal.7b01296

Reference yield: 92.0%

4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate (1060771-60-9) → 1,1,1-trichloro-2-methylpropan-2-yl 4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate (1060771-66-5)

Guidance literature:

With 3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; In dichloromethane; at 20 - 25 ℃; for 1h;

DOI:10.1039/b805850d

upstream raw materials:

2,2,2-trichloro-1,1-dimethylethoxychloroformate

4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole

Downstream raw materials:

1,1,1-trichloro-2-methylpropan-2-yl 4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

(R)-1,1,1-trichloro-2-methylpropan-2-yl-4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

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