Methanesulfonic acid (1R,2R)-1,2-dimethyl-2-p-tolyl-cyclopentylmethyl ester

Base Information

Chemical Name:Methanesulfonic acid (1R,2R)-1,2-dimethyl-2-p-tolyl-cyclopentylmethyl ester
CAS No.:117421-45-1
Molecular Formula:C₁₆H₂₄O₃S
Molecular Weight:296.431
Hs Code.:

Synonyms:Methanesulfonic acid (1R,2R)-1,2-dimethyl-2-p-tolyl-cyclopentylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methanesulfonic acid (1R,2R)-1,2-dimethyl-2-p-tolyl-cyclopentylmethyl ester

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Technology Process of Methanesulfonic acid (1R,2R)-1,2-dimethyl-2-p-tolyl-cyclopentylmethyl ester

There total 14 articles about Methanesulfonic acid (1R,2R)-1,2-dimethyl-2-p-tolyl-cyclopentylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

: 51941-57-2,117421-43-9
(1R^*,2S^*)-1,2-Dimethyl-2-(4-methylphenyl)cyclopentanemethanol

: 124-63-0
methanesulfonyl chloride

: 117421-45-1
Methanesulfonic acid (1R,2R)-1,2-dimethyl-2-p-tolyl-cyclopentylmethyl ester

Guidance literature:: With triethylamine; In dichloromethane; 0 deg C, then room t., 10 min;

Reference yield:

: 1821-23-4
1-cyclohex-1-enyl-4-methylbenzene

: 117421-45-1
Methanesulfonic acid (1R,2R)-1,2-dimethyl-2-p-tolyl-cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) -78 deg C to room t.

2: Jones reagent / acetone / 0.5 h / 0 °C

3: 87.2 percent / 95 percent H₂SO₄ / 5 h / Heating

4: 75 percent / diethyl ether; toluene / 0.5 h / -78 °C

5: 81.5 percent / ZnI₂ / 1,2-dichloro-ethane / 0.17 h / Ambient temperature

6: 1.) BuLi(hexane), (i-Pr)2NH / 1.) THF, -78 deg C, 1 h 2.) THF, -78 deg C, 1 h, to room t.

7: 100 percent / p-MeC₆H₄SO₂N₃, Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

8: multistep reaction; reactions under var. conditions

9: 90 percent / NaBH₄, NiCl₂*6H₂O / methanol / 24 h / Ambient temperature

10: 1.) BuLi(hexane), (i-Pr)NH / 1.) HMPA, THF, 0 deg C, 2 h, 2.) HMPA, THF, 0 deg C to room t., 2 h

11: 91.2 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

12: 99.4 percent / Et₃N / CH₂Cl₂ / 0 deg C, then room t., 10 min

With sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; 4-toluenesulfonyl azide; jones reagent; dimethylsulfide; (i-Pr)NH; ozone; triethylamine; diisopropylamine; nickel dichloride; sulfuric acid; zinc(II) iodide; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetone; toluene;

Reference yield:

: 1821-24-5
1-(p-methylphenyl)cyclohexanol

: 117421-45-1
Methanesulfonic acid (1R,2R)-1,2-dimethyl-2-p-tolyl-cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: p-TsOH / benzene / 16 h / Heating

2: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) -78 deg C to room t.

3: Jones reagent / acetone / 0.5 h / 0 °C

4: 87.2 percent / 95 percent H₂SO₄ / 5 h / Heating

5: 75 percent / diethyl ether; toluene / 0.5 h / -78 °C

6: 81.5 percent / ZnI₂ / 1,2-dichloro-ethane / 0.17 h / Ambient temperature

7: 1.) BuLi(hexane), (i-Pr)2NH / 1.) THF, -78 deg C, 1 h 2.) THF, -78 deg C, 1 h, to room t.

8: 100 percent / p-MeC₆H₄SO₂N₃, Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

9: multistep reaction; reactions under var. conditions

10: 90 percent / NaBH₄, NiCl₂*6H₂O / methanol / 24 h / Ambient temperature

11: 1.) BuLi(hexane), (i-Pr)NH / 1.) HMPA, THF, 0 deg C, 2 h, 2.) HMPA, THF, 0 deg C to room t., 2 h

12: 91.2 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

13: 99.4 percent / Et₃N / CH₂Cl₂ / 0 deg C, then room t., 10 min

With sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; 4-toluenesulfonyl azide; jones reagent; dimethylsulfide; (i-Pr)NH; ozone; triethylamine; diisopropylamine; nickel dichloride; sulfuric acid; toluene-4-sulfonic acid; zinc(II) iodide; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetone; toluene; benzene;