N-[(2R,Z)-3-fluoro-2-(phenylmethoxy)propylidene]-benzenemethanamine N-oxide

Base Information

Chemical Name:N-[(2R,Z)-3-fluoro-2-(phenylmethoxy)propylidene]-benzenemethanamine N-oxide
CAS No.:242804-99-5
Molecular Formula:C₁₇H₁₈FNO₂
Molecular Weight:287.334
Hs Code.:

Synonyms:N-[(2R,Z)-3-fluoro-2-(phenylmethoxy)propylidene]-benzenemethanamine N-oxide

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Chemical Property of N-[(2R,Z)-3-fluoro-2-(phenylmethoxy)propylidene]-benzenemethanamine N-oxide

Chemical Property:

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Technology Process of N-[(2R,Z)-3-fluoro-2-(phenylmethoxy)propylidene]-benzenemethanamine N-oxide

There total 4 articles about N-[(2R,Z)-3-fluoro-2-(phenylmethoxy)propylidene]-benzenemethanamine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 29601-98-7
N-benzylhydroxylamine hydrochloride

: 124568-19-0
(2S)-2-benzyloxy-3-fluoropropanal

: 242804-99-5
N-[(2R,Z)-3-fluoro-2-(phenylmethoxy)propylidene]-benzenemethanamine N-oxide

Guidance literature:: With sodium carbonate; calcium chloride; In methanol; at 20 ℃; for 2h;
DOI:10.1002/(sici)1099-0690(199907)1999:7<1665::aid-ejoc1665>3.0.co;2-d

Reference yield:

: 100-39-0
benzyl bromide

: 242804-99-5
N-[(2R,Z)-3-fluoro-2-(phenylmethoxy)propylidene]-benzenemethanamine N-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / NaH / tetrahydrofuran; dimethylformamide

2: sym-collidine / acetonitrile / -25 - 20 °C

3: Hg₂Cl₂; K₂CO₃ / acetonitrile / 2.5 h / -10 - 20 °C

4: 70 percent / Na₂CO₃; CaCl₂ / methanol / 2 h / 20 °C

With 2,4,6-trimethyl-pyridine; mercury(I) chloride; sodium hydride; sodium carbonate; potassium carbonate; calcium chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; 1: Etherification / 2: Acylation / 3: Elimination / 4: Condensation;
DOI:10.1002/(sici)1099-0690(199907)1999:7<1665::aid-ejoc1665>3.0.co;2-d

Reference yield:

: 124568-12-3
(2S,R_S)-2-benzyloxy-3-fluoro-1-(p-tolylsulphinyl)propane

: 242804-99-5
N-[(2R,Z)-3-fluoro-2-(phenylmethoxy)propylidene]-benzenemethanamine N-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: sym-collidine / acetonitrile / -25 - 20 °C

2: Hg₂Cl₂; K₂CO₃ / acetonitrile / 2.5 h / -10 - 20 °C

3: 70 percent / Na₂CO₃; CaCl₂ / methanol / 2 h / 20 °C

With 2,4,6-trimethyl-pyridine; mercury(I) chloride; sodium carbonate; potassium carbonate; calcium chloride; In methanol; acetonitrile; 1: Acylation / 2: Elimination / 3: Condensation;
DOI:10.1002/(sici)1099-0690(199907)1999:7<1665::aid-ejoc1665>3.0.co;2-d