(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)(thymin-1-yl) methane

Base Information

• Chemical Name: (2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)(thymin-1-yl) methane
• CAS No.: 175672-61-4
• Molecular Formula: C₂₇H₂₈N₂O₇
• Molecular Weight: 492.529
• Mol file: 175672-61-4.mol

Synonyms:(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)(thymin-1-yl) methane

Chemical Property of (2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)(thymin-1-yl) methane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)(thymin-1-yl) methane

There total 5 articles about (2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)(thymin-1-yl) methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)methyl]-N'-(3-methoxy-2-methylacryloyl)urea → (2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)(thymin-1-yl) methane (175672-61-4)

Guidance literature:

With hydrogenchloride; acetic acid; at 25 ℃; for 16h;

DOI:10.1021/jo961548k

Reference yield:

(E)-3-methoxy-2-methylacryloyl isocyanate (132151-65-6) → (2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)(thymin-1-yl) methane (175672-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / benzene / 16 h / 25 °C

2: conc. HCl / acetic acid / 16 h / 25 °C

With hydrogenchloride; triethylamine; In acetic acid; benzene;

DOI:10.1016/0960-894X(95)00589-L

Reference yield:

Hoffer's chlorosugar (3601-89-6,4330-21-6,52304-86-6,3056-12-0,141846-57-3) → (2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)(thymin-1-yl) methane (175672-61-4)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene; tetrahydrofuran / 7 h / 25 °C

2: 1.) BH₃, 2.) HCl(gas)/MeOH / 1.) THF, 25 deg C, 1 h, 2.) 0 deg C, 10 min

3: Et₃N / benzene / 16 h / 25 °C

4: conc. HCl / acetic acid / 16 h / 25 °C

With hydrogenchloride; methanol; borane; triethylamine; In tetrahydrofuran; acetic acid; toluene; benzene;

DOI:10.1016/0960-894X(95)00589-L

upstream raw materials:

Hoffer's chlorosugar

methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose

(E)-3-methoxy-2-methylacryloyl isocyanate

1-Amino-2,5-anhydro-1,3-dideoxy-4,6-di-O-p-toluyl-D-ribo-hexitol hydrochloride

Downstream raw materials:

5'-O-(4,4'-dimethoxytriphenylmethyl)thymidine

1-{(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl}-5-methyl-1H-pyrimidine-2,4-dione