methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Base Information

Chemical Name:methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate
CAS No.:1350650-30-4
Molecular Formula:C₃₆H₃₅N₅O₅
Molecular Weight:617.704
Hs Code.:

Synonyms:methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

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Chemical Property of methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

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Technology Process of methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

There total 7 articles about methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 578-66-5
8-amino quinoline

: C₁₈H₂₁Cl₂NO₅

: 1350650-30-4
methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Guidance literature:: With pyridine; at -60 - -20 ℃; for 0.5h;

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 1350650-30-4
methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Cooling with ice

1.2: 1.17 h / 20 - 120 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Cooling with ice

4.1: trifluoroacetic acid / dichloromethane / 19 h / 20 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / 0.5 h / -30 - -15 °C

6.1: pyridine / 0.5 h / -60 - -20 °C

With pyridine; oxalyl dichloride; potassium tert-butylate; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 278791-31-4
di-t-butyl 2-(4-nitrophenyl)malonate

: 1350650-30-4
methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Cooling with ice

3: trifluoroacetic acid / dichloromethane / 19 h / 20 °C

4: oxalyl dichloride / N,N-dimethyl-formamide / 0.5 h / -30 - -15 °C

5: pyridine / 0.5 h / -60 - -20 °C

With pyridine; oxalyl dichloride; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; N,N-dimethyl-formamide; In ethanol; dichloromethane;