methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Base Information

Chemical Name:methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate
CAS No.:1350650-28-0
Molecular Formula:C₁₈H₂₃NO₇
Molecular Weight:365.383
Hs Code.:

Synonyms:methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

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Chemical Property of methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

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Technology Process of methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

There total 5 articles about methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350650-29-1
di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)malonate

: 1350650-28-0
methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 19h;

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 1350650-28-0
methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Cooling with ice

1.2: 1.17 h / 20 - 120 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Cooling with ice

4.1: trifluoroacetic acid / dichloromethane / 19 h / 20 °C

With potassium tert-butylate; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 278791-31-4
di-t-butyl 2-(4-nitrophenyl)malonate

: 1350650-28-0
methyl 8-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Cooling with ice

3: trifluoroacetic acid / dichloromethane / 19 h / 20 °C

With ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane;