methyl 2-(4-fluorophenyl)-5-(2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxylate

Base Information

Chemical Name:methyl 2-(4-fluorophenyl)-5-(2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxylate
CAS No.:1215107-69-9
Molecular Formula:C₃₁H₂₄FN₃O₄
Molecular Weight:521.548
Hs Code.:

Synonyms:methyl 2-(4-fluorophenyl)-5-(2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxylate

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Chemical Property of methyl 2-(4-fluorophenyl)-5-(2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxylate

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Technology Process of methyl 2-(4-fluorophenyl)-5-(2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxylate

There total 7 articles about methyl 2-(4-fluorophenyl)-5-(2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 437985-36-9
1-(pyridin-2-yl)cyclopropan-1-amine dihydrochloride

: 1215107-04-2
3-(2-(4-fluorophenyl)-3-(methoxycarbonyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoic acid

: 1215107-69-9
methyl 2-(4-fluorophenyl)-5-(2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1215107-69-9
methyl 2-(4-fluorophenyl)-5-(2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; copper(l) iodide / trans-bis(triphenylphosphine)palladium dichloride / 2 h / 90 °C / Inert atmosphere

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

2.2: 1 h

3.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 20 °C / flask was wrapped in aluminum foil

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C

5.1: 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 80 °C / 7757.43 Torr / Parr bomb

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

With N-Bromosuccinimide; copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1215106-68-5
5-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridine

: 1215107-69-9
methyl 2-(4-fluorophenyl)-5-(2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

1.2: 1 h

2.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 20 °C / flask was wrapped in aluminum foil

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C

4.1: 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 80 °C / 7757.43 Torr / Parr bomb

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

With N-Bromosuccinimide; 1,3-bis-(diphenylphosphino)propane; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;