3,2'-bis-1,6:6',4'-N,O-dicarbonyl-2'',3''-O-cyclohexylidene-3'-O-toluenesulfonyl-5''-O-(triphenylmethyl)ribostamycin

Base Information

Chemical Name:3,2'-bis-1,6:6',4'-N,O-dicarbonyl-2'',3''-O-cyclohexylidene-3'-O-toluenesulfonyl-5''-O-(triphenylmethyl)ribostamycin
CAS No.:72163-44-1
Molecular Formula:C₆₇H₇₀N₄O₁₈S
Molecular Weight:1251.37
Hs Code.:

3,2'-bis<N-(benzyloxycarbonyl)>-1,6:6',4'-N,O-dicarbonyl-2'',3''-O-cyclohexylidene-3'-O-toluenesulfonyl-5''-O-(triphenylmethyl)ribostamycin

Synonyms:3,2'-bis-1,6:6',4'-N,O-dicarbonyl-2'',3''-O-cyclohexylidene-3'-O-toluenesulfonyl-5''-O-(triphenylmethyl)ribostamycin

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Chemical Property of 3,2'-bis-1,6:6',4'-N,O-dicarbonyl-2'',3''-O-cyclohexylidene-3'-O-toluenesulfonyl-5''-O-(triphenylmethyl)ribostamycin

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Technology Process of 3,2'-bis-1,6:6',4'-N,O-dicarbonyl-2'',3''-O-cyclohexylidene-3'-O-toluenesulfonyl-5''-O-(triphenylmethyl)ribostamycin

There total 6 articles about 3,2'-bis-1,6:6',4'-N,O-dicarbonyl-2'',3''-O-cyclohexylidene-3'-O-toluenesulfonyl-5''-O-(triphenylmethyl)ribostamycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 72163-43-0
C₆₀H₆₄N₄O₁₆

: 98-59-9
p-toluenesulfonyl chloride

: 72163-44-1
3,2'-bis-1,6:6',4'-N,O-dicarbonyl-2'',3''-O-cyclohexylidene-3'-O-toluenesulfonyl-5''-O-(triphenylmethyl)ribostamycin

Guidance literature:: In pyridine; at 25 ℃; for 48h;
DOI:10.1021/jm00175a009

Reference yield:

: 933-40-4
cycloxexanone dimethyl ketal

: 72163-44-1
3,2'-bis-1,6:6',4'-N,O-dicarbonyl-2'',3''-O-cyclohexylidene-3'-O-toluenesulfonyl-5''-O-(triphenylmethyl)ribostamycin

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / p-toluenesulfonic acid / dimethylformamide / 2 h / 50 - 60 °C

2: 90 percent / pyridine / 48 h / 25 °C

With toluene-4-sulfonic acid; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jm00175a009

Reference yield:

: 76-83-5
trityl chloride

: 72163-44-1
3,2'-bis-1,6:6',4'-N,O-dicarbonyl-2'',3''-O-cyclohexylidene-3'-O-toluenesulfonyl-5''-O-(triphenylmethyl)ribostamycin

Guidance literature:: Multi-step reaction with 4 steps

1: 84.6 percent / pyridine / 24 h / 25 °C

2: 88 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 25 deg C, 2 h

3: 99 percent / p-toluenesulfonic acid / dimethylformamide / 2 h / 50 - 60 °C

4: 90 percent / pyridine / 48 h / 25 °C

With sodium hydride; toluene-4-sulfonic acid; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jm00175a009