N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea

Base Information

• Chemical Name: N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea
• CAS No.: 862370-64-7
• Molecular Formula: C₁₉H₁₇Cl₂FN₄O
• Molecular Weight: 407.275

Synonyms:N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea

Chemical Property of N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea

Chemical Property:

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Technology Process of N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea

There total 1 articles about N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(2,6-Dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-amine (293301-19-6) + Tert-butyl isocyanate (1609-86-5) → N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea (862370-64-7)

Guidance literature:

3-(2,6-Dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-amine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0333333h;

Tert-butyl isocyanate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

DOI:10.1021/jm0500931

Reference yield: 75.0%

N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea (862370-64-7) + 4-(diethylamino)butylamine (27431-62-5) → N-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]-N'-[4-(diethylamino)butyl]urea + N-[3-(2,6-dichlorophenyl)-7-[[4-(diethylamino)butyl]amino]-1,6-naphthyridin-2-yl]-N'-[4-(diethylamino)butyl]urea + 3-(2,6-Dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-amine (293301-19-6)

Guidance literature:

In various solvent(s); at 120 ℃; for 2h;

DOI:10.1021/jm0500931

Reference yield: 75.0%

N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea (862370-64-7) + 3-(N-methylpiperazino)propylamine (4572-03-6) → N-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]-N'-[3-(4-methyl-1-piperazinyl)propyl]urea + N-[3-(2,6-dichlorophenyl)-7-[[3-(4-methyl-1-piperazinyl)propyl]amino]-1,6-naphthyridin-2-yl]-N'-[3-(4-methyl-1-piperazinyl)propyl]urea + 3-(2,6-Dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-amine (293301-19-6) + 3-(2,6-Dichlorophenyl)-7-{[3-(4-methylpiperazin-1-yl)propyl]amino}-1,6-naphthyridin-2-amine (293301-33-4)

Guidance literature:

In various solvent(s); at 120 ℃; for 2h;

DOI:10.1021/jm0500931

upstream raw materials:

3-(2,6-Dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-amine

Tert-butyl isocyanate

Downstream raw materials:

3-(2,6-Dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-amine

3-(2,6-Dichlorophenyl)-7-{[3-(4-methylpiperazin-1-yl)propyl]amino}-1,6-naphthyridin-2-amine

3-(2,6-dichloro-phenyl)-N⁷-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine

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