1-(3-Aminopropyl)-4-methylpiperazine

Base Information

• Chemical Name: 1-(3-Aminopropyl)-4-methylpiperazine
• CAS No.: 4572-03-6
• Molecular Formula: C8H19N3
• Molecular Weight: 157.259
• Hs Code.: 29335990
• European Community (EC) Number: 224-954-4
• NSC Number: 60215
• DSSTox Substance ID: DTXSID0063527
• Nikkaji Number: J297.827J
• Wikidata: Q81990800
• ChEMBL ID: CHEMBL158701
• Mol file: 4572-03-6.mol

Synonyms:4572-03-6;1-(3-Aminopropyl)-4-methylpiperazine;3-(4-methylpiperazin-1-yl)propan-1-amine;1-Piperazinepropanamine, 4-methyl-;3-(4-Methyl-piperazin-1-yl)-propylamine;3-(4-Methyl-1-piperazinyl)propylamine;NSC60215;4-(3-Aminopropyl)-1-methylpiperazine;3-(4-Methylpiperazin-1-yl)propylamine;1-Methyl-4-(3'-aminopropyl)piperazine;MFCD00014616;NSC 60215;N-Methyl-N'-(3-aminopropyl)piperazine;1-(3-aminopropyl)-4-methyl-piperazine;Piperazine, 1-(3-aminopropyl)-4-methyl-;NSC-60215;3-(4-Methylpiperazin-1-yl)propanamine;N-Methyl-N'-(.gamma.-aminopropyl)piperazine;4-methyl-1-piperazinepropanamine;NCIStruc1_000253;NCIStruc2_000087;SCHEMBL248151;CHEMBL158701;DTXSID0063527;N-methyl-N'-aminopropylpiperazine;3-(4-methylpiperazino)propylamine;1-(aminopropyl)-4-methylpiperazine;BCP33244;NCI60215;EINECS 224-954-4;4-Methyl-1-piperazinepropan-1-amine;CCG-36244;NCGC00013716;STK500385;1-(3-aminopropyl)-4-methylpiperizine;3-(4-methylpiperazino)-1-propanamine;4-methyl-1-(3-aminopropyl)piperazine;AKOS000201165;(2-ethyl-1H-imidazol-1-yl)aceticacid;3-(1-methylpiperazin-4-yl)propylamine;3-(4-methylpiperazino)-1-propaneamine;LF-0539;N-(3-aminopropyl)-N'-methylpiperazine;1-(3-aminopropyl)-4-methyl piperazine;3-(4-methylpiperazin-1-yl)-propylamine;N-methyl-N'-(3-aminopropyl)-piperazine;NCGC00013716-02;NCGC00096827-01;[3-(4-methyl-1-piperazinyl)propyl]amine;NCI60_004553;N-Methyl-N'-(gamma-aminopropyl)piperazine;3-(4-methyl- piperazin-1-yl)-propylamine;3-(4-methyl-piperazin-1-yl)- propylamine;3-(4-methyl-piperazin-1-yl)--propylamine;3-(4-methylpiperazin-1-yl)-propan-1-amine;CS-0033789;N-(.gamma.-Aminopropyl)-N'-methylpiperazine;EN300-13957;H11827;A850958;3-(4-Methyl-1-piperazinyl)propylamine, AldrichCPR;N-METHYL-N'-(3-AMINO PROPYL) PIPERAZINE HCL

Chemical Property of 1-(3-Aminopropyl)-4-methylpiperazine

Chemical Property:

• Vapor Pressure: 0.0674mmHg at 25°C
• Refractive Index: 1.4810
• Boiling Point: 230 °C at 760 mmHg
• PKA: 10.39±0.10(Predicted)
• Flash Point: 92 °C
• PSA: 32.50000
• Density: 0.945 g/cm³
• LogP: 0.15870
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air Sensitive
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 157.157897619
• Heavy Atom Count: 11
• Complexity: 97.5

Purity/Quality:

98%min ^*data from raw suppliers

1-(3-Aminoprop-1-yl)-4-methylpiperazine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)CCCN
• Uses: 1-(3-Aminopropyl)-4-methylpiperazine is used as a precursor in organic synthesis for the preparation of furan-2-carboxylic acid [3-(4-methyl-piperazin-1-yl)-propyl]-amide by reacting with furan-2-carbonyl chloride.

Technology Process of 1-(3-Aminopropyl)-4-methylpiperazine

There total 8 articles about 1-(3-Aminopropyl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.9%

3-(4-methylpiperazin-1-yl)propanenitrile (4491-92-3) → 3-(N-methylpiperazino)propylamine (4572-03-6)

Guidance literature:

With ammonia; hydrogen; In methanol; at 40 ℃; for 1h; under 7500.75 Torr; Reagent/catalyst; Temperature; Solvent; Pressure; Autoclave;

Reference yield: 86.0%

2-(3-(N-methylpiperazin-4-yl)propyl)-1H-isoindole-1,3(2H)-dione (6820-96-8) → 3-(N-methylpiperazino)propylamine (4572-03-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 24h; Reflux;

DOI:10.1016/j.ejmech.2019.01.052

Reference yield: 48.0%

→ 3-(N-methylpiperazino)propylamine (4572-03-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 24h; Reflux;

upstream raw materials:

3-(4-methylpiperazin-1-yl)propanenitrile

dimethyl amine

2-(3-(N-methylpiperazin-4-yl)propyl)-1H-isoindole-1,3(2H)-dione

1-methyl-piperazine

Downstream raw materials:

(2-Acetamidophenyl)-N-<3-(4-methylpiperazinyl)propyl>glyoxylamid

7-Chloro-3-(3,4-dichloro-phenyl)-10-hydroxy-1-[(E)-3-(4-methyl-piperazin-1-yl)-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one

1-{4-[3-(4-Methyl-piperazin-1-yl)-propylamino]-3-nitro-phenyl}-ethanone

1-<3-(4-methyl-1-piperazinyl)propyl>-3,4-diphenyl-1H-pyrrole-2,5-dione

Refernces

• 1、 Tazarki, Helmi,Zeinyeh, Wael,Esvan, Yannick J.,Knapp, Stefan,Chatterjee, Deep,Schr?der, Martin,Joerger, Andreas C.,Khiari, Jameleddine,Josselin, Béatrice,Baratte, Blandine,Bach, Stéphane,Ruchaud, Sandrine,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale. "New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis". . p. 304 - 317. Retrieved 2019/02/07.
• 2、 Dola, Vasantha Rao,Soni, Awakash,Agarwal, Pooja,Ahmad, Hafsa,Raju, Kanumuri Siva Rama,Rashid, Mamunur,Wahajuddin, Muhammad,Srivastava, Kumkum,Haq,Dwivedi,Puri,Katti. "Synthesis and evaluation of chirally defined side chain variants of 7-chloro-4-aminoquinoline to overcome drug resistance in malaria chemotherapy". . . Retrieved 2017/03/09.