4'-{[3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile

Base Information

Chemical Name:4'-{[3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile
CAS No.:917357-28-9
Molecular Formula:C₂₂H₂₄FN₃O₂S
Molecular Weight:413.516
Hs Code.:

Synonyms:4'-{[3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile

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Chemical Property of 4'-{[3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile

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Technology Process of 4'-{[3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile

There total 3 articles about 4'-{[3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917357-91-6
4'-[(3-oxo-pyrrolidin-1-yl)sulfonyl]biphenyl-4-carbonitrile

: 78197-27-0
4-fluoropiperidine

: 917357-28-9
4'-{[3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 16h; Product distribution / selectivity;

Reference yield:

: 57395-89-8
4-fluoropiperidine hydrochloride

: 917357-28-9
4'-{[3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide

2: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran; dimethyl sulfoxide / 16 h / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In tetrahydrofuran; dimethyl sulfoxide;