4-Fluoropiperidine hydrochloride

Base Information

• Chemical Name: 4-Fluoropiperidine hydrochloride
• CAS No.: 57395-89-8
• Molecular Formula: C₅H₁₀FN*ClH
• Molecular Weight: 139.6
• Hs Code.: 29333990
• European Community (EC) Number: 624-705-3,948-889-2
• DSSTox Substance ID: DTXSID90374661
• Mol file: 57395-89-8.mol

Synonyms:4-Fluoropiperidine hydrochloride;57395-89-8;4-FLUOROPIPERIDINE HCl;4-fluoropiperidine;hydrochloride;MFCD03452786;Piperidine, 4-fluoro-, hydrochloride;SCHEMBL63302;4-fluoro-piperidine hydrochloride;DTXSID90374661;IXENWFQXVCOHAZ-UHFFFAOYSA-N;4-fluoranylpiperidine hydrochloride;BCP34607;AKOS005146259;4-Fluoropiperidine hydrochloride, 97%;PB24811;PS-9061;SY010389;AM20100405;CS-0040905;FT-0654088;EN300-398588;A831424;J-515419;Z1741960061

Chemical Property of 4-Fluoropiperidine hydrochloride

Chemical Property:

• Melting Point: 163-167 °C
• Boiling Point: 120.2oC at 760mmHg
• Flash Point: 26.5oC
• PSA: 12.03000
• LogP: 1.83870
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 139.0564052
• Heavy Atom Count: 8
• Complexity: 50

Purity/Quality:

99.0% ^*data from raw suppliers

4-Fluoropiperidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,C,Xi
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1F.Cl

Technology Process of 4-Fluoropiperidine hydrochloride

There total 3 articles about 4-Fluoropiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-HYDROXYPIPERIDINE (5382-16-1) + 4-fluoropiperidine hydrochloride (57395-89-8)

Guidance literature:

Reference yield:

4-fluoropiperidine (78197-27-0) → 4-fluoropiperidine hydrochloride (57395-89-8)

Guidance literature:

With hydrogenchloride; In diethyl ether;

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 4-fluoropiperidine hydrochloride (57395-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / -78 - 20 °C

2: hydrogen / palladium(II) hydroxide/carbon / ethanol / 12 h / 2068.65 Torr

With hydrogen; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium(II) hydroxide/carbon; In ethanol; dichloromethane;

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

4-fluoropiperidine

Downstream raw materials:

4'-{[(3R)-3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carboxylic acid

4'-{[(3R)-3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile

4'-{[(3S)-3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile

4'-{[3-(4-fluoro-piperidin-1-yl)pyrrolidin-1-yl]sulfonyl}biphenyl-4-carbonitrile

Refernces

• 1、 -. "1,2,4-OXADIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES". Page/Page column 40. . Retrieved 2010/02/14.
• 2、 -. "Fluorodehydroxylation of serine". . . Retrieved 2008/06/13.