(S)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Base Information

Chemical Name:(S)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one
CAS No.:134018-59-0
Molecular Formula:C₁₅H₂₂N₄O
Molecular Weight:274.366
Hs Code.:

Synonyms:(S)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

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Technology Process of (S)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

There total 7 articles about (S)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 134000-08-1
2-{1,1-Dimethyl-2-[4-((S)-4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione

: 134018-59-0
(S)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: With hydrazinium monoacetate; In ethanol; for 3h; Heating;
DOI:10.1248/cpb.46.84

Reference yield:

: 616-02-4
citraconic acid anhydride

: 134018-59-0
(S)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 34 percent / AlCl₃, DMF / 3 h / 70 °C

2: 60 percent / H₂, (R)-Ru(OAc)2BINAP / methanol / 48 h / 60800 Torr / Ambient temperature

3: 90 percent / hydrazine acetate / ethanol / 0.5 h / Heating

4: 61 percent / hydrazine acetate / methanol / 48 h / Heating

5: 1.) AcOH, 2.) NaBH₃CN / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, overnight

6: 90 percent / hydrazine acetate / ethanol / 3 h / Heating

With aluminium trichloride; (R)-Ru(OCOCH₃)2(binap); hydrogen; hydrazinium monoacetate; sodium cyanoborohydride; acetic acid; N,N-dimethyl-formamide; In methanol; ethanol;
DOI:10.1248/cpb.46.84

Reference yield:

: 139052-03-2
3-(p-Acetamidobenzoyl)-crotonsaeure

: 134018-59-0
(S)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / H₂, (R)-Ru(OAc)2BINAP / methanol / 48 h / 60800 Torr / Ambient temperature

2: 90 percent / hydrazine acetate / ethanol / 0.5 h / Heating

3: 61 percent / hydrazine acetate / methanol / 48 h / Heating

4: 1.) AcOH, 2.) NaBH₃CN / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, overnight

5: 90 percent / hydrazine acetate / ethanol / 3 h / Heating

With (R)-Ru(OCOCH₃)2(binap); hydrogen; hydrazinium monoacetate; sodium cyanoborohydride; acetic acid; In methanol; ethanol;
DOI:10.1248/cpb.46.84