2-Hydroxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-{(2E,4E)-6-[3-(4-benzoyl-phenyl)-propionylamino]-hexa-2,4-dienoylamino}-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester

Base Information

Chemical Name:2-Hydroxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-{(2E,4E)-6-[3-(4-benzoyl-phenyl)-propionylamino]-hexa-2,4-dienoylamino}-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester
CAS No.:1027853-79-7
Molecular Formula:C₄₉H₆₄N₂O₇Si
Molecular Weight:821.142
Hs Code.:

2-Hydroxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-{(2E,4E)-6-[3-(4-benzoyl-phenyl)-propionylamino]-hexa-2,4-dienoylamino}-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester

Synonyms:2-Hydroxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-{(2E,4E)-6-[3-(4-benzoyl-phenyl)-propionylamino]-hexa-2,4-dienoylamino}-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Hydroxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-{(2E,4E)-6-[3-(4-benzoyl-phenyl)-propionylamino]-hexa-2,4-dienoylamino}-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-Hydroxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-{(2E,4E)-6-[3-(4-benzoyl-phenyl)-propionylamino]-hexa-2,4-dienoylamino}-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester

There total 19 articles about 2-Hydroxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-{(2E,4E)-6-[3-(4-benzoyl-phenyl)-propionylamino]-hexa-2,4-dienoylamino}-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852327-41-4
2-Allyloxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-((2E,4E)-6-allyloxycarbonylamino-hexa-2,4-dienoylamino)-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester

: 161364-95-0
4-(benzoyl)benzenepropanoic acid N-hydroxysuccinimide ester

: 1027853-79-7
2-Hydroxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-{(2E,4E)-6-[3-(4-benzoyl-phenyl)-propionylamino]-hexa-2,4-dienoylamino}-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylammonium borohydride; macroporous methylpolystyrene; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 9h;
DOI:10.1021/jo0477751

Reference yield:

: 852327-34-5
Triisopropyl-((R)-2-oxiranyl-ethoxy)-silane

: 1027853-79-7
2-Hydroxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-{(2E,4E)-6-[3-(4-benzoyl-phenyl)-propionylamino]-hexa-2,4-dienoylamino}-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 90 percent / BF₃*OEt₂ / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

2.1: 2789 mg / camphorsulfonic acid / CH₂Cl₂ / 12 h / 20 °C

3.1: 99 percent / K₂CO₃ / methanol / 1 h / 20 °C

4.1: Cp₂ZrHCl / CH₂Cl₂ / 0.75 h / 20 °C

4.2: 88 percent / I₂ / CH₂Cl₂; tetrahydrofuran / 0.33 h / 20 °C

5.1: 93 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 0.5 h / 20 °C

6.1: 91 percent / NaHMDS / tetrahydrofuran / 0.5 h / 0 °C

7.1: 95 percent / NaH / dimethylformamide; various solvent(s) / 20 h / 20 °C

8.1: 51 percent / copper(I) thiophene-2-carboxylate; N,N'-dimethylethylenediamine; Cs₂CO₃ / tetrahydrofuran; N,N-dimethyl-acetamide / 11 h / 50 °C

9.1: triethylammonium borohydride/macroporous methylpolystyrene; Pd(PPh₃)4 / tetrahydrofuran; N,N-dimethyl-acetamide / 9 h / 20 °C

With Schwartz's reagent; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; copper(I) thiophene-2-carboxylate; triethylammonium borohydride; macroporous methylpolystyrene; camphor-10-sulfonic acid; sodium hexamethyldisilazane; sodium hydride; potassium carbonate; caesium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0477751

Reference yield:

: 852327-38-9
6-allyloxycarbonylamino-hexa-2,4-dienoic acid

: 1027853-79-7
2-Hydroxy-6-(3-methyl-but-2-enyl)-benzoic acid (E)-(S)-4-{(2E,4E)-6-[3-(4-benzoyl-phenyl)-propionylamino]-hexa-2,4-dienoylamino}-1-(2-triisopropylsilanyloxy-ethyl)-but-3-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

1.2: 63 percent / ammonium hydroxide / tetrahydrofuran; H₂O / 1.5 h / 20 °C

2.1: 51 percent / copper(I) thiophene-2-carboxylate; N,N'-dimethylethylenediamine; Cs₂CO₃ / tetrahydrofuran; N,N-dimethyl-acetamide / 11 h / 50 °C

3.1: triethylammonium borohydride/macroporous methylpolystyrene; Pd(PPh₃)4 / tetrahydrofuran; N,N-dimethyl-acetamide / 9 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; triethylammonium borohydride; macroporous methylpolystyrene; chloroformic acid ethyl ester; caesium carbonate; triethylamine; N,N`-dimethylethylenediamine; In tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1021/jo0477751