1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

Base Information

• Chemical Name: 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone
• CAS No.: 181870-69-9
• Molecular Formula: C₂₀H₁₆F₂N₆O₂
• Molecular Weight: 410.383
• Mol file: 181870-69-9.mol

Synonyms:1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

Chemical Property of 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

There total 11 articles about 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

methanesulfonyl chloride (124-63-0) + 1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2,3-dihydroxy-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one (325988-95-2) → 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone (181870-69-9)

Guidance literature:

methanesulfonyl chloride; 1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2,3-dihydroxy-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one; With triethylamine; In tetrahydrofuran; ethyl acetate; at 0 ℃; for 0.5h;

With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 1h;

DOI:10.1248/cpb.48.1935

Reference yield: 7.7%

Trifluoro-methanesulfonic acid (S)-1-[(R)-2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl ester + 1-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone (181870-66-6) → 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone (181870-69-9)

Guidance literature:

With sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; N,N-dimethyl-formamide; at -30 - 0 ℃; for 1h;

DOI:10.1248/cpb.48.1935

Reference yield:

(2S,3R)-3-(2,4-Difluorophenyl)-3,4-epoxy-2-butanol (150802-96-3) + 1-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone (181870-66-6) → 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone (181870-69-9)

Guidance literature:

With sodium chloride; dimethyl sulfoxide; trifluoromethanesulfonic acid anhydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N-methyl-acetamide; hexane; dichloromethane; water;

upstream raw materials:

methanesulfonyl chloride

1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2,3-dihydroxy-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one

1-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

4-tetrazol-1-yl-phenylamine

Downstream raw materials:

1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-(1H,3H)-imidazolone

1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone