(2S,3S,E)-2-(tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)hex-4-enoic acid

Base Information

Chemical Name:(2S,3S,E)-2-(tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)hex-4-enoic acid
CAS No.:944805-42-9
Molecular Formula:C₁₈H₂₂F₃NO₄
Molecular Weight:373.372
Hs Code.:

Synonyms:(2S,3S,E)-2-(tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)hex-4-enoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,E)-2-(tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)hex-4-enoic acid

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Technology Process of (2S,3S,E)-2-(tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)hex-4-enoic acid

There total 2 articles about (2S,3S,E)-2-(tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)hex-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 944805-40-7
(S,E)-4-(4-(trifluoromethyl)phenyl)but-3-en-2-yl 2-(tert-butoxycarbonylamino)acetate

: 944805-42-9
(2S,3S,E)-2-(tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)hex-4-enoic acid

Guidance literature:: (S,E)-4-(4-(trifluoromethyl)phenyl)but-3-en-2-yl 2-(tert-butoxycarbonylamino)acetate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - -20 ℃; for 0.416667h;

With zinc(II) chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h;

With hydrogenchloride; water; In tetrahydrofuran; hexane;

Reference yield:

: (E)-4-(4-(trifluoromethyl)phenyl)but-3-en-2-yl 2-(tert-butoxycarbonylamino)acetate

: 944805-42-9
(2S,3S,E)-2-(tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)hex-4-enoic acid

: (2R,3R,E)-2-(tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)hex-4-enoic acid

Guidance literature:: (E)-4-(4-(trifluoromethyl)phenyl)but-3-en-2-yl 2-(tert-butoxycarbonylamino)acetate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃;

With zinc(II) chloride; In tetrahydrofuran; hexane; at 20 ℃;