1-Benzyl-4-(3,4-dihydro-2,2-dioxo-2,1,3-benzothiadiazin-1-yl)-piperidine monohydrochloride

Base Information

Chemical Name:1-Benzyl-4-(3,4-dihydro-2,2-dioxo-2,1,3-benzothiadiazin-1-yl)-piperidine monohydrochloride
CAS No.:79099-05-1
Molecular Formula:C₁₉H₂₃N₃O₂S*ClH
Molecular Weight:393.937
Hs Code.:

Synonyms:SCHEMBL11102754;PPFRWWHMBSRQIB-UHFFFAOYSA-N;1-Benzyl-4-(3,4-dihydro-2,2-dioxo-2,1,3-benzothiadiazin-1-yl)-piperidine monohydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Benzyl-4-(3,4-dihydro-2,2-dioxo-2,1,3-benzothiadiazin-1-yl)-piperidine monohydrochloride

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:393.1277759
Heavy Atom Count:26
Complexity:533

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1N2C3=CC=CC=C3CNS2(=O)=O)CC4=CC=CC=C4.Cl

Technology Process of 1-Benzyl-4-(3,4-dihydro-2,2-dioxo-2,1,3-benzothiadiazin-1-yl)-piperidine monohydrochloride

There total 2 articles about 1-Benzyl-4-(3,4-dihydro-2,2-dioxo-2,1,3-benzothiadiazin-1-yl)-piperidine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.6%

: 79098-90-1
1-benzyl-4-[N-(o-aminomethylphenyl)-amino]-piperidine

: 79099-05-1
1-benzyl-4-(3,4-dihydro-2,2-dioxo-1H-2,1,3-benzothiadiazin-1-yl)piperidine.HCl

Guidance literature:: With pyridine; SULFAMIDE; for 8h; Heating;
DOI:10.1248/cpb.33.1104

Reference yield:

: 7803-58-9
SULFAMIDE

: 79098-90-1
1-benzyl-4-[N-(o-aminomethylphenyl)-amino]-piperidine

: 79099-05-1
1-benzyl-4-(3,4-dihydro-2,2-dioxo-1H-2,1,3-benzothiadiazin-1-yl)piperidine.HCl

Guidance literature:: With pyridine; hydrogenchloride; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; chloroform; ethyl acetate;

Reference yield:

: 79099-05-1
1-benzyl-4-(3,4-dihydro-2,2-dioxo-1H-2,1,3-benzothiadiazin-1-yl)piperidine.HCl

: 79098-46-7
1-(3,4-dimethoxybenzoylmethyl)-4-(3,4-dihydro-2,2-dioxo-1H-2,1,3-benzothiadiazin-1-yl)-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 49.1 percent / hydrogen / 10percent Pd-C / H₂O; methanol / 20 h / 40 °C

2: 83.2 percent / TEA / dimethylformamide / 48 h / Ambient temperature

With TEA; hydrogen; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.1104