Sulfamide

Base Information Edit

Chemical Name:Sulfamide
CAS No.:7803-58-9
Molecular Formula:H4N2O2S
Molecular Weight:96.11
Hs Code.:28530090
European Community (EC) Number:232-262-9
NSC Number:252
UNII:VS7TZW634V
DSSTox Substance ID:DTXSID5064885
Nikkaji Number:J134.318A
Wikipedia:Sulfamide
Wikidata:Q3048282
Pharos Ligand ID:KL5DSHS1MS5D
ChEMBL ID:CHEMBL355001
Mol file:7803-58-9.mol

Synonyms:Sulfamide;Sulfuric diamide;7803-58-9;Sulfamamide;Sulfuryl amide;sulphamide;Sulfonyl diamide;Sulfuryl diamide;sulfamoylamine;Sulphuric diamide;H4N2O2S;Imidosulfamic acid;MFCD00011606;Imidosulfamic acid (VAN);H2NSO2NH2;UNII-VS7TZW634V;VS7TZW634V;CHEMBL355001;CHEBI:29368;NSC 252;NSC-252;EINECS 232-262-9;AI3-30237;Sulfuricdiamide;aminosulfonamide;diamidodioxidosulfur;Sulfamide, 99%;SULFAMIDE [MI];NH2SO2NH2;NSC252;DTXSID5064885;BDBM26995;H4-N2-O2-S;[S(NH2)2O2];BCP13844;STR07407;BBL019229;S O2 (N H2)2;STK505662;Sulfamide, purum, >=99.0% (N);AKOS000201755;CCG-266025;CS-W013732;s12311;SY004124;BB 0260582;FT-0601025;S5606;A839317;Q-201768;Q3048282;Z104503438;FUS

Suppliers and Price of Sulfamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Sulfamide
100mg
$ 403.00

Usbiological
Sulfamide
100g
$ 333.00

TRC
Sulfamide
5g
$ 90.00

TCI Chemical
Sulfamide >96.0%(N)
25g
$ 25.00

TCI Chemical
Sulfamide >96.0%(N)
250g
$ 122.00

SynQuest Laboratories
Sulfamide 98%
500 g
$ 184.00

SynQuest Laboratories
Sulfamide 98%
100 g
$ 61.00

Sigma-Aldrich
Sulfamide purum, ≥99.0% (N)
50g
$ 341.00

Sigma-Aldrich
Sulfamide 99%
25g
$ 43.00

Sigma-Aldrich
Sulfamide 99%
5g
$ 102.00

Total 168 raw suppliers

Chemical Property of Sulfamide Edit

Chemical Property:

Appearance/Colour:White solid
Melting Point:90-92 °C(lit.)
Refractive Index:1.548
PKA:10.87±0.60(Predicted)
PSA：94.56000
Density:1.688 g/cm³
LogP:0.63000
Storage Temp.:Refrigerator
Sensitive.:Moisture Sensitive
Solubility.:water: soluble50mg/mL, clear, colorless to faintly yellow
Water Solubility.:soluble
XLogP3:-1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:95.99934855
Heavy Atom Count:5
Complexity:85.3

Purity/Quality:

98% ^*data from raw suppliers

Sulfamide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:NS(=O)(=O)N
Description Sulfamide is a white solid substance that is normally produced by reacting sulfuryl chloride with ammonia. Sulfamide is stable under normal conditions and soluble in acetone and DMSO. Sulfamide may also refer to the functional group in organic chemistry, and it consists of at least one group attached to a nitrogen atom of sulfamide. It is a carbonic anhydrase inhibitor and is widely used as a pharmaceutical intermediate. Sulfamide is sensitive to moisture, thus should be kept away from water and humidity. It should also be stored away from oxidizing agents. Sulfamide should be kept in a tightly closed container and placed in a cool, dry, and well-ventilated condition.
Uses Similar to urea in many of its reactions, but is more acidic, and can act as a dibasic acid. A carbonic anhydrase inhibitor; used for treatment of cancer. Sulfamide and its derivatives can also be used to prepare fused thiadiazine systems, Reaction with 2-aminoacetophenones affords IH-2,1,3-benzothia- diazine 2,2-dioxides 77 (65JOC3960). The corresponding 3,4-dihydro deriv- atives are readily available from 2-aminobenzylamines with either sulfuryl chloride (70M1443) or sulfamide (66USP3278532; 71MI055). These kinds of compounds can also be obtained from N-aryl-N'-alkylsulfamides and s-trioxane in a reaction involving cyclization by intramolecular sulfamido- methylation (79JOC2032) (Scheme 30).

Technology Process of Sulfamide

There total 46 articles about Sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 7791-25-5
sulfuryl dichloride

: 7664-41-7
ammonia

: 7803-58-9
SULFAMIDE

Guidance literature:: In Petroleum ether; addn. of SO2Cl2 in dry petroleum ether to liquid NH3 (cooling: solid CO2 in CHCl3/CCl4); removal of cooling (removal of excess NH3); decanting of solvent; warming; - further information (to diminish vehemence of reaction) given;; extraction (soxhlet/CH3COOCH3); evapn.; drying (vac.); recrystn. from water; further information (extraction/increase of yield) given;;