1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Base Information

• Chemical Name: 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione
• CAS No.: 1566577-65-8
• Molecular Formula: C₃₇H₃₅F₄N₅O₆
• Molecular Weight: 721.708
• Mol file: 1566577-65-8.mol

Synonyms:1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Chemical Property of 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

There total 13 articles about 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine (1290538-61-2) + (E)-5-((dimethylamino)methylene)-1-(2-(trifluoromethyl)phenyl)pyrimidine-2,4,6-trione (1566577-49-8) → 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (1566577-65-8)

Guidance literature:

With acetic acid; at 80 ℃;

DOI:10.1016/j.bmc.2014.01.014

Reference yield:

1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (1566577-65-8)

Guidance literature:

Multi-step reaction with 9 steps

1: acetone / 12.5 h / 0 - 20 °C

2: nitric acid / dichloromethane / 4 h / 0 °C

3: toluene / 10 h / 110 °C

4: iron; acetic acid / 2.5 h / 20 - 80 °C

5: acetonitrile / 10 h / 85 °C

6: trichlorophosphate / 6 h / 85 °C

7: chlorobenzene / 30 h / 140 °C

8: iron; ammonium chloride / ethanol; water / 5 h / Reflux

9: acetic acid / 80 °C

With nitric acid; iron; ammonium chloride; acetic acid; trichlorophosphate; In ethanol; dichloromethane; water; chlorobenzene; acetone; toluene; acetonitrile;

DOI:10.1016/j.bmc.2014.01.014

Reference yield:

4-(3-chloropropoxy)-3-methoxyacetophenone (58113-30-7) → 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (1566577-65-8)

Guidance literature:

Multi-step reaction with 8 steps

1: nitric acid / dichloromethane / 4 h / 0 °C

2: toluene / 10 h / 110 °C

3: iron; acetic acid / 2.5 h / 20 - 80 °C

4: acetonitrile / 10 h / 85 °C

5: trichlorophosphate / 6 h / 85 °C

6: chlorobenzene / 30 h / 140 °C

7: iron; ammonium chloride / ethanol; water / 5 h / Reflux

8: acetic acid / 80 °C

With nitric acid; iron; ammonium chloride; acetic acid; trichlorophosphate; In ethanol; dichloromethane; water; chlorobenzene; toluene; acetonitrile;

DOI:10.1016/j.bmc.2014.01.014

upstream raw materials:

1-(3-methoxy-4-hydroxyphenyl)ethanone

4-(3-chloropropoxy)-3-methoxyacetophenone

1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one