(S)-2-[2-(Isoquinolin-5-yloxy)-acetylamino]-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester

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Chemical Name:(S)-2-[2-(Isoquinolin-5-yloxy)-acetylamino]-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester
CAS No.:566939-10-4
Molecular Formula:C₄₂H₄₉N₅O₈S
Molecular Weight:783.946
Hs Code.:

(S)-2-[2-(Isoquinolin-5-yloxy)-acetylamino]-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester

Synonyms:(S)-2-[2-(Isoquinolin-5-yloxy)-acetylamino]-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester

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Chemical Property of (S)-2-[2-(Isoquinolin-5-yloxy)-acetylamino]-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester

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Technology Process of (S)-2-[2-(Isoquinolin-5-yloxy)-acetylamino]-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester

There total 8 articles about (S)-2-[2-(Isoquinolin-5-yloxy)-acetylamino]-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80278-25-7
5-isoquinolinyloxyacetic acid

: (S)-2-Amino-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester

: 566939-10-4
(S)-2-[2-(Isoquinolin-5-yloxy)-acetylamino]-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0968-0896(02)00322-X

Reference yield:

: 62023-65-8,76498-21-0,77171-41-6,82848-28-0,105181-72-4,116661-86-0
(2S,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutanoic acid

: 566939-10-4
(S)-2-[2-(Isoquinolin-5-yloxy)-acetylamino]-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 11.7 g / EDC*HCl; HOBt; Et₃N / dimethylformamide / 20 °C

2: 4 N HCl / dioxane / 2 h / 20 °C

3: 3.45 g / Et₃N / dimethylformamide / 4 h / 20 °C

4: 91 percent / DCC; DMAP / CH₂Cl₂; dimethylformamide / 20 °C

5: 4 N HCl / dioxane / 2 h / 20 °C

6: 238 mg / EDC*HCl; HOBt; Et₃N / dimethylformamide / 20 °C

With hydrogenchloride; dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00322-X

Reference yield:

: 128019-19-2
(R)-N-tert-butyl-1,3-thiazolidine-4-carboxamide

: 566939-10-4
(S)-2-[2-(Isoquinolin-5-yloxy)-acetylamino]-pentanoic acid (1S,2S)-2-benzyloxycarbonylamino-1-((R)-4-tert-butylcarbamoyl-thiazolidine-3-carbonyl)-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 11.7 g / EDC*HCl; HOBt; Et₃N / dimethylformamide / 20 °C

2: 4 N HCl / dioxane / 2 h / 20 °C

3: 3.45 g / Et₃N / dimethylformamide / 4 h / 20 °C

4: 91 percent / DCC; DMAP / CH₂Cl₂; dimethylformamide / 20 °C

5: 4 N HCl / dioxane / 2 h / 20 °C

6: 238 mg / EDC*HCl; HOBt; Et₃N / dimethylformamide / 20 °C

With hydrogenchloride; dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00322-X