methyl 3-(bromomethyl)-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Base Information

Chemical Name:methyl 3-(bromomethyl)-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
CAS No.:1335116-74-9
Molecular Formula:C₂₃H₂₁BrF₃NO₅S
Molecular Weight:560.389
Hs Code.:

Synonyms:methyl 3-(bromomethyl)-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Chemical Property of methyl 3-(bromomethyl)-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Technology Process of methyl 3-(bromomethyl)-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

There total 10 articles about methyl 3-(bromomethyl)-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335116-43-2
methyl 3-methyl-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 1335116-74-9
methyl 3-(bromomethyl)-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 100 ℃;

Reference yield:

: 19056-40-7
4-bromo-3-methoxyaniline

: 1335116-74-9
methyl 3-(bromomethyl)-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane; water / 50 °C

1.2: 1 h / 80 °C

2.1: sulfuric acid / 1 h / 50 - 80 °C

3.1: potassium hydroxide / ethanol; water / 16 h / Reflux

3.2: pH 3

4.1: caesium carbonate / dimethyl sulfoxide / 2 h / 20 °C

5.1: copper(l) iodide / dimethyl sulfoxide / 50 - 120 °C / Inert atmosphere

5.2: 1 h / 20 °C

6.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

With hydrogenchloride; N-Bromosuccinimide; copper(l) iodide; sulfuric acid; caesium carbonate; potassium hydroxide; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 1335116-74-9
methyl 3-(bromomethyl)-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / Reflux

1.2: 20 °C / Reflux

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.33 h

2.2: 100 °C

2.3: 2 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

With N-Bromosuccinimide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; mineral oil;