1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-pyrrolidin-2-one

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Chemical Name:1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-pyrrolidin-2-one
CAS No.:1092938-50-5
Molecular Formula:C₂₃H₂₅N₃O₂
Molecular Weight:375.47
Hs Code.:

Synonyms:1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-pyrrolidin-2-one

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Chemical Property of 1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-pyrrolidin-2-one

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Technology Process of 1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-pyrrolidin-2-one

There total 7 articles about 1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 927-58-2
4-bromobutyroyl chloride

: 1092938-52-7
(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-amine

: 1092938-50-5
1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-pyrrolidin-2-one

Guidance literature:: 4-bromobutyroyl chloride; (8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-amine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/j.tetlet.2009.04.071

Reference yield:

: 927-58-2
4-bromobutyroyl chloride

: 1092938-52-7
(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-amine

: 1092938-54-9
N-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-cyclopropane-carboxamide

: 1092938-50-5
1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-pyrrolidin-2-one

Guidance literature:: 4-bromobutyroyl chloride; (8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-amine; With triethylamine; In tetrahydrofuran; at 10 - 50 ℃; for 3h;

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 917957-11-0
BYK 405879

: 1092938-54-9
N-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-cyclopropane-carboxamide

: 1092938-50-5
1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethylene glycol / 48 h / 195 °C

1.2: 3 h / 20 °C / pH 4 - 5

2.1: diphenyl phosphoryl azide; triethylamine / 3 h / Heating / reflux

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 3 h / 10 - 50 °C

4.2: 16 h / 20 °C

With sodium hydroxide; diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethylene glycol;