(R)-4-((1S,2R,3R)-2,4-Bis-benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

Base Information

Chemical Name:(R)-4-((1S,2R,3R)-2,4-Bis-benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane
CAS No.:477781-64-9
Molecular Formula:C₂₆H₃₆O₄
Molecular Weight:412.569
Hs Code.:

Synonyms:(R)-4-((1S,2R,3R)-2,4-Bis-benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

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Chemical Property of (R)-4-((1S,2R,3R)-2,4-Bis-benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

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Technology Process of (R)-4-((1S,2R,3R)-2,4-Bis-benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

There total 5 articles about (R)-4-((1S,2R,3R)-2,4-Bis-benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 100-39-0
benzyl bromide

: 477781-63-8
(2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentan-1-ol

: 477781-64-9
(R)-4-((1S,2R,3R)-2,4-Bis-benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 3h; Heating;
DOI:10.1016/S0040-4039(02)01705-7

Reference yield:

: 96691-92-8
(1R,2R,3r,4S,5S)-3-(benzyloxy)-2,4-dimethyl-8-oxa-bicyclo[3.2.1]oct-6-ene

: 477781-64-9
(R)-4-((1S,2R,3R)-2,4-Bis-benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 5 steps

1.1: (-)-diisopinocamphenylborane / 24 h / -23 °C

1.2: 96 percent / 3N NaOH; 30 percent H₂O₂ / 6 h / 25 °C

2.1: PCC / CH₂Cl₂ / 3 h / 25 °C

2.2: 76 percent / m-CPBA; NaHCO₃ / CH₂Cl₂ / 10 h / 25 °C

3.1: 92 percent / LiAlH₄ / tetrahydrofuran / 4 h / 0 - 25 °C

4.1: 95 percent / CSA / CH₂Cl₂ / 1 h / 25 °C

5.1: 98 percent / NaH / tetrahydrofuran / 3 h / Heating

With lithium aluminium tetrahydride; camphor-10-sulfonic acid; sodium hydride; diisopinocampheylborane; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(02)01705-7

Reference yield:

: 171231-72-4
endo-3-benzyloxy-endo,endo-2,4-dimethyl-exo-6-hydroxy-8-oxabicyclo[3.2.1]octane

: 477781-64-9
(R)-4-((1S,2R,3R)-2,4-Bis-benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 4 steps

1.1: PCC / CH₂Cl₂ / 3 h / 25 °C

1.2: 76 percent / m-CPBA; NaHCO₃ / CH₂Cl₂ / 10 h / 25 °C

2.1: 92 percent / LiAlH₄ / tetrahydrofuran / 4 h / 0 - 25 °C

3.1: 95 percent / CSA / CH₂Cl₂ / 1 h / 25 °C

4.1: 98 percent / NaH / tetrahydrofuran / 3 h / Heating

With lithium aluminium tetrahydride; camphor-10-sulfonic acid; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(02)01705-7