pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}-methanone

Base Information

Chemical Name:pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}-methanone
CAS No.:1432050-76-4
Molecular Formula:C₁₉H₁₆F₃NO₃
Molecular Weight:363.336
Hs Code.:

Synonyms:pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}-methanone

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Chemical Property of pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}-methanone

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Technology Process of pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}-methanone

There total 4 articles about pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 109-04-6
2-bromo-pyridine

: 1432050-74-2
2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile

: 1432050-76-4
pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}-methanone

Guidance literature:: 2-bromo-pyridine; With n-butyllithium; In diethyl ether; hexane; at -75 ℃; for 1.5h;

2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile; In diethyl ether; hexane; at -75 - 0 ℃; for 3h;

Reference yield:

: 2338-76-3
3-trifluoromethylphenylacetonitrile

: 1432050-76-4
pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether; tetrahydrofuran / 1 h / -75 °C

1.2: 1 h / -75 °C

1.3: -75 - 20 °C

2.1: Dess-Martin periodane / dichloromethane / 20 °C

3.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 °C

4.1: n-butyllithium / hexane; diethyl ether / 1.5 h / -75 °C

4.2: 3 h / -75 - 0 °C

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;

Reference yield:

: 1379098-58-4
3-oxo-1-[3-(trifluoromethyl)phenyl]cyclobutanecarbonitrile

: 1432050-76-4
pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / 1.5 h / -75 °C

2.2: 3 h / -75 - 0 °C

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; In diethyl ether; hexane; dichloromethane;