(2R)-2-[(3E)-6-(tert-butyldiphenylsilanyloxy)hex-3-enyl]-2-[(Z)-3-(4-nitrobenzenesulfonyamino)prop-1-enyl]succinic acid dimethyl ester

Base Information

Chemical Name:(2R)-2-[(3E)-6-(tert-butyldiphenylsilanyloxy)hex-3-enyl]-2-[(Z)-3-(4-nitrobenzenesulfonyamino)prop-1-enyl]succinic acid dimethyl ester
CAS No.:939054-91-8
Molecular Formula:C₃₇H₄₆N₂O₉SSi
Molecular Weight:722.932
Hs Code.:

Synonyms:(2R)-2-[(3E)-6-(tert-butyldiphenylsilanyloxy)hex-3-enyl]-2-[(Z)-3-(4-nitrobenzenesulfonyamino)prop-1-enyl]succinic acid dimethyl ester

Suppliers and Price of (2R)-2-[(3E)-6-(tert-butyldiphenylsilanyloxy)hex-3-enyl]-2-[(Z)-3-(4-nitrobenzenesulfonyamino)prop-1-enyl]succinic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R)-2-[(3E)-6-(tert-butyldiphenylsilanyloxy)hex-3-enyl]-2-[(Z)-3-(4-nitrobenzenesulfonyamino)prop-1-enyl]succinic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R)-2-[(3E)-6-(tert-butyldiphenylsilanyloxy)hex-3-enyl]-2-[(Z)-3-(4-nitrobenzenesulfonyamino)prop-1-enyl]succinic acid dimethyl ester

There total 7 articles about (2R)-2-[(3E)-6-(tert-butyldiphenylsilanyloxy)hex-3-enyl]-2-[(Z)-3-(4-nitrobenzenesulfonyamino)prop-1-enyl]succinic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 939054-97-4
C₃₆H₄₂N₂O₈SSi

: 124-41-4
sodium methylate

: 939054-91-8
(2R)-2-[(3E)-6-(tert-butyldiphenylsilanyloxy)hex-3-enyl]-2-[(Z)-3-(4-nitrobenzenesulfonyamino)prop-1-enyl]succinic acid dimethyl ester

Guidance literature:: In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;
DOI:10.1021/jo070144x

Reference yield:

: 939054-89-4
(5E)-8-(tert-butyldiphenylsilanyloxy)-2-(diethoxyphosphoryl)oct-5-enoic acid methyl ester

: 939054-91-8
(2R)-2-[(3E)-6-(tert-butyldiphenylsilanyloxy)hex-3-enyl]-2-[(Z)-3-(4-nitrobenzenesulfonyamino)prop-1-enyl]succinic acid dimethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / Ba(OH)2 / tetrahydrofuran; H₂O / 5 h / 20 °C

2.1: 86 percent / Et₃SiH; trifluoroacetic acid / CH₂Cl₂ / 0.33 h / 0 °C

3.1: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 0.08 h / 0 °C

4.1: LHMDS / toluene; hexane / 0.33 h / -78 °C

4.2: 55 percent / toluene; hexane / 0.17 h / Heating

5.1: 80 percent / NaHMDS / tetrahydrofuran / 3 h / -78 °C

6.1: 89 percent / tetrahydrofuran; methanol / 0.5 h / 20 °C

With triethylsilane; dmap; barium dihydroxide; sodium hexamethyldisilazane; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene; 1.1: Horner-Wadsworth-Emmons reaction / 4.2: aza-Claisen rearrangement;
DOI:10.1021/jo070144x

Reference yield:

: 939054-94-1
(5E)-8-(tert-butyldiphenylsilanyloxy)-2-((2R,E)-1-tritylaziridin-2-ylmethylene)oct-5-enoic acid methyl ester

: 939054-91-8
(2R)-2-[(3E)-6-(tert-butyldiphenylsilanyloxy)hex-3-enyl]-2-[(Z)-3-(4-nitrobenzenesulfonyamino)prop-1-enyl]succinic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 86 percent / Et₃SiH; trifluoroacetic acid / CH₂Cl₂ / 0.33 h / 0 °C

2.1: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 0.08 h / 0 °C

3.1: LHMDS / toluene; hexane / 0.33 h / -78 °C

3.2: 55 percent / toluene; hexane / 0.17 h / Heating

4.1: 80 percent / NaHMDS / tetrahydrofuran / 3 h / -78 °C

5.1: 89 percent / tetrahydrofuran; methanol / 0.5 h / 20 °C

With triethylsilane; dmap; sodium hexamethyldisilazane; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; 3.2: aza-Claisen rearrangement;
DOI:10.1021/jo070144x