(-)-Verapamil

Base Information Edit

Chemical Name:(-)-Verapamil
CAS No.:36622-29-4
Molecular Formula:C27H38N2O4
Molecular Weight:454.61
Hs Code.:
European Community (EC) Number:253-133-3
UNII:9P7619E627
DSSTox Substance ID:DTXSID301017708
Nikkaji Number:J221.682E
Wikidata:Q27147328
Pharos Ligand ID:C4BSNYL5S881
Metabolomics Workbench ID:132830
ChEMBL ID:CHEMBL36148
Mol file:36622-29-4.mol

Synonyms:(-)-verapamil;36622-29-4;(S)-(-)-verapamil;(S)-VERAPAMIL;(S) Verapamil;(-)-(S)-verapamil;CHEMBL36148;(-)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile;CHEBI:77736;(S)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile;9P7619E627;(2S)-2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;(2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile;s-verapamil;verapamil-s;4YH;Tocris-0654;starbld0017717;Lopac-V-4629;CAS-152-11-4;NCIMech_000868;VERAPAMIL, (-)-;BIDD:GT0587;SCHEMBL14874635;DTXSID301017708;UNII-9P7619E627;VERAPAMIL (S)-FORM [MI];2-(3,4-dimethoxy-phenyl)-5-{[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino}-2-isopropyl-pentanenitrile;EINECS 253-133-3;BDBM50005628;NCGC00016083-01;NCGC00016083-02;NCGC00016083-03;NCGC00016083-12;NCGC00016412-01;NCGC00024710-01;NCGC00686699-01;Q27147328;(-)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile;2-(3,4-Dimethoxy-phenyl)-5-{[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino}-2-isopropyl-pentanenitrile(verapamil);BENZENEACETONITRILE, .ALPHA.-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4-DIMETHOXY-.ALPHA.-(1-METHYLETHYL)-, (.ALPHA.S)-;BENZENEACETONITRILE, .ALPHA.-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4-DIMETHOXY-.ALPHA.-(1-METHYLETHYL)-, (S)-;Benzeneacetonitrile, alpha-(3((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha(1-methylethyl)-, (alpha,S)-

Suppliers and Price of (-)-Verapamil

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(S)-(-)-VerapamilHCl
1 mg
$ 925.00

Biosynth Carbosynth
(-)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-Dimethoxyphenethyl)Methylamino]Hexane-3-Carbonitrile
2 mg
$ 578.10

Biosynth Carbosynth
(-)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-Dimethoxyphenethyl)Methylamino]Hexane-3-Carbonitrile
1 mg
$ 318.00

Biosynth Carbosynth
(-)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-Dimethoxyphenethyl)Methylamino]Hexane-3-Carbonitrile
10 mg
$ 1911.00

Biosynth Carbosynth
(-)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-Dimethoxyphenethyl)Methylamino]Hexane-3-Carbonitrile
5 mg
$ 1051.10

American Custom Chemicals Corporation
(S)-(-)-VERAPAMIL 95.00%
10MG
$ 2194.50

American Custom Chemicals Corporation
(S)-(-)-VERAPAMIL 95.00%
1MG
$ 779.63

Total 5 raw suppliers

Chemical Property of (-)-Verapamil Edit

Chemical Property:

Vapor Pressure:1.01E-13mmHg at 25°C
Melting Point:126-129°C
Boiling Point:586.1°Cat760mmHg
Flash Point:308.3°C
PSA：63.95000
Density:1.058g/cm³
LogP:4.84708
Storage Temp.:-20°C Freezer
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:13
Exact Mass:454.28315770
Heavy Atom Count:33
Complexity:606

Purity/Quality:

98%Min ^*data from raw suppliers

(S)-(-)-VerapamilHCl ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
Isomeric SMILES:CC(C)[C@](CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
Uses Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells

Technology Process of (-)-Verapamil

There total 66 articles about (-)-Verapamil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%