(2S)-(-)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Base Information

Chemical Name:(2S)-(-)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile
CAS No.:36622-26-1
Molecular Formula:C₁₆H₂₂ClNO₂
Molecular Weight:295.809
Hs Code.:

Synonyms:(2S)-(-)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

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Chemical Property of (2S)-(-)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Chemical Property:

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Technology Process of (2S)-(-)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

There total 33 articles about (2S)-(-)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 36770-70-4
(2S)-(-)-2-(3,4-dimethoxyphenyl)-5-hydroxy-2-isopropylpentanenitrile

: 36622-26-1
(2S)-(-)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Guidance literature:: With triphenylphosphine; In tetrachloromethane; for 2h; Heating;
DOI:10.1002/1099-0690(200104)2001:7<1349::AID-EJOC1349>3.0.CO;2-9

Reference yield:

: (Z)-4-(3,4-Dimethoxy-phenyl)-5-methyl-hex-3-en-2-ol

: 36622-26-1
(2S)-(-)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Guidance literature:: Multi-step reaction with 15 steps

1.1: lipase PS (Burkholderia cepacia) / diethyl ether / 18 h / 20 °C / Enzymatic reaction

2.1: lithium diisopropylamide / tetrahydrofuran / 0.08 h / -78 °C

2.2: trimethylchlorosilane / tetrahydrofuran / 3 h / Heating

2.3: methanol / 0.17 h / 20 °C

3.1: 97 percent / diethyl ether

4.1: 91 percent / DIBAL-H / toluene / 1 h / 20 °C

5.1: 90 percent / pyridine

6.1: 84 percent / dimethylsulfoxide / 2 h / 80 °C

7.1: 79 percent / 20percent KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating

8.1: 97 percent / diethyl ether

9.1: 80 percent / DIBAL-H / toluene / 1 h / 20 °C

10.1: 98 percent / pyridine

11.1: 69 percent / ozone; triphenylphosphane / CH₂Cl₂; methanol

12.1: hydroxylamine hydrochloride; sodium acetate / ethanol

13.1: 1.19 g / sodium acetate / acetic anhydride / Heating

14.1: potassium hydroxide / methanol / 2 h / Heating

15.1: 95 percent / triphenylphosphane / CCl₄ / 2 h / Heating

With pyridine; potassium hydroxide; lipase PS (Burkholderia cepacia); hydroxylamine hydrochloride; sodium acetate; diisobutylaluminium hydride; ozone; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; acetic anhydride; dimethyl sulfoxide; toluene; diethylene glycol; 2.1: Ireland rearrangement;
DOI:10.1002/1099-0690(200104)2001:7<1349::AID-EJOC1349>3.0.CO;2-9

Reference yield:

: 255721-21-2
(4S)-(-)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl acetate

: 36622-26-1
(2S)-(-)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / methanol / 2 h / Heating

2: 95 percent / triphenylphosphane / CCl₄ / 2 h / Heating

With potassium hydroxide; triphenylphosphine; In methanol; tetrachloromethane;
DOI:10.1002/1099-0690(200104)2001:7<1349::AID-EJOC1349>3.0.CO;2-9