2(R)-(4-methanesulfonyl-phenyl)-3-cyclopentyl-5-bromo-pyrazin-2-yl-propionamide

Base Information

Chemical Name:2(R)-(4-methanesulfonyl-phenyl)-3-cyclopentyl-5-bromo-pyrazin-2-yl-propionamide
CAS No.:710322-14-8
Molecular Formula:C₁₉H₂₂BrN₃O₃S
Molecular Weight:452.372
Hs Code.:

Synonyms:2(R)-(4-methanesulfonyl-phenyl)-3-cyclopentyl-5-bromo-pyrazin-2-yl-propionamide

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Chemical Property of 2(R)-(4-methanesulfonyl-phenyl)-3-cyclopentyl-5-bromo-pyrazin-2-yl-propionamide

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Technology Process of 2(R)-(4-methanesulfonyl-phenyl)-3-cyclopentyl-5-bromo-pyrazin-2-yl-propionamide

There total 2 articles about 2(R)-(4-methanesulfonyl-phenyl)-3-cyclopentyl-5-bromo-pyrazin-2-yl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 300355-22-0
(2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)propionic acid

: 113305-94-5
2-amino-5-cyanopyrazine

: 710322-14-8
2(R)-(4-methanesulfonyl-phenyl)-3-cyclopentyl-5-bromo-pyrazin-2-yl-propionamide

Guidance literature:: With pyridine; N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 ℃; for 0.25h;

(2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)propionic acid; In dichloromethane; at 25 ℃; for 0.166667h;

2-amino-5-cyanopyrazine; With pyridine; In dichloromethane; at 25 ℃; for 3h;

Reference yield:

: 59489-71-3
5-amino-2-bromopyrazine

: C₁₅H₁₉ClO₃S

: 710322-14-8
2(R)-(4-methanesulfonyl-phenyl)-3-cyclopentyl-5-bromo-pyrazin-2-yl-propionamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 83.0%

: potassium cyanide

: 710322-14-8
2(R)-(4-methanesulfonyl-phenyl)-3-cyclopentyl-5-bromo-pyrazin-2-yl-propionamide

: 710322-15-9
2(R)-(4-methanesulfonyl-phenyl)-3-cyclopentyl-5-cyano-pyrazin-2-yl-propionamide

Guidance literature:: With copper(l) iodide; 18-crown-6 ether; tetrakis (triphenylphosphine) palladium ⁽⁰⁾; In DMF (N,N-dimethyl-formamide); at 150 ℃; for 4h;