ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-nitrobenzoate

Base Information

Chemical Name:ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-nitrobenzoate
CAS No.:1235166-22-9
Molecular Formula:C₂₅H₃₃N₃O₈
Molecular Weight:503.552
Hs Code.:

Synonyms:ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-nitrobenzoate

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Chemical Property of ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-nitrobenzoate

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Technology Process of ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-nitrobenzoate

There total 1 articles about ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 13171-25-0,127881-54-3
trimetazidine dihydrochloride

: 386213-23-6
ethyl 4-(2-bromoethoxy)-3-nitrobenzoate

: 1235166-22-9
ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-nitrobenzoate

Guidance literature:: trimetazidine dihydrochloride; With potassium hydroxide; In water; pH=Ca. 11;

ethyl 4-(2-bromoethoxy)-3-nitrobenzoate; With potassium carbonate; In acetonitrile; for 4h; Reflux;
DOI:10.1016/j.ejmech.2011.06.011

Reference yield: 98.0%

: 1235166-22-9
ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-nitrobenzoate

: 1235166-28-5
ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-aminobenzoate

Guidance literature:: With hydrogenchloride; iron; In ethanol; water; for 1h; Reflux;
DOI:10.1016/j.ejmech.2011.06.011

Reference yield:

: 1235166-22-9
ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-nitrobenzoate

: 1235166-59-2
ethyl 4-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)-3-(4-methylphenylsulfonamido)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; iron / ethanol; water / 1 h / Reflux

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With hydrogenchloride; iron; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.06.011