2-benzyloxymethyl-5-[2-(2,3-difluoro-phenyl)-ethyl]-pyrazolo[1,5-a]pyrimidin-7-ol

Base Information

Chemical Name:2-benzyloxymethyl-5-[2-(2,3-difluoro-phenyl)-ethyl]-pyrazolo[1,5-a]pyrimidin-7-ol
CAS No.:1185908-14-8
Molecular Formula:C₂₂H₁₉F₂N₃O₂
Molecular Weight:395.409
Hs Code.:

Synonyms:2-benzyloxymethyl-5-[2-(2,3-difluoro-phenyl)-ethyl]-pyrazolo[1,5-a]pyrimidin-7-ol

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Chemical Property of 2-benzyloxymethyl-5-[2-(2,3-difluoro-phenyl)-ethyl]-pyrazolo[1,5-a]pyrimidin-7-ol

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Technology Process of 2-benzyloxymethyl-5-[2-(2,3-difluoro-phenyl)-ethyl]-pyrazolo[1,5-a]pyrimidin-7-ol

There total 2 articles about 2-benzyloxymethyl-5-[2-(2,3-difluoro-phenyl)-ethyl]-pyrazolo[1,5-a]pyrimidin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185908-13-7,393590-62-0
5-[(phenylmethoxy)methyl]-1H-pyrazol-3-amine

: 412950-62-0
5-(2,3-difluoro-phenyl)-3-oxo-pentanoic acid ethyl ester

: 1185908-14-8
2-benzyloxymethyl-5-[2-(2,3-difluoro-phenyl)-ethyl]-pyrazolo[1,5-a]pyrimidin-7-ol

Guidance literature:: With acetic acid; for 10h; Reflux;

Reference yield:

: 100-39-0
benzyl bromide

: 1185908-14-8
2-benzyloxymethyl-5-[2-(2,3-difluoro-phenyl)-ethyl]-pyrazolo[1,5-a]pyrimidin-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.92 h / 0 °C / Inert atmosphere

1.2: 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrazine hydrate / ethanol / 10 h / Reflux

4.1: acetic acid / 10 h / Reflux

With n-butyllithium; sodium hydride; hydrazine hydrate; acetic acid; In tetrahydrofuran; hexanes; ethanol;